CYP4F12

Gene Name		cytochrome P450, family 4, subfamily F, polypeptide 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Leukotriene-B4 20-monooxygenase Activity Aromatase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Xenobiotic Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Blood Coagulation Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Vitamin K Biosynthetic Process Small Molecule Metabolic Process Sodium Ion Homeostasis Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Eicosanoids Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: HSPA6 SOD2
Entrez ID		66002
HPRD ID		07102
Ensembl ID		ENSG00000186204
Uniprot IDs		Q9HCS2
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Temperature Stimulus Erythrophore Differentiation Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Age-dependent Response To Reactive Oxygen Species Response To Magnetism Response To Silicon Dioxide Age-dependent Response To Oxidative Stress Detection Of Oxygen Response To Selenium Ion Oxygen Homeostasis Cellular Response To Ethanol Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Response To L-ascorbic Acid Removal Of Superoxide Radicals Superoxide Anion Generation Cellular Response To Superoxide Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Refolding Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Response To Superoxide Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Immobilization Stress Response To Oxygen Radical Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Abiotic Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Release Of Cytochrome C From Mitochondria Response To Hyperoxia Regulation Of Mitochondrial Membrane Potential Vasodilation Hydrogen Peroxide Metabolic Process Negative Regulation Of Fibroblast Proliferation Superoxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Electrical Stimulus Response To Zinc Ion Negative Regulation Of Blood Pressure Regulation Of Cellular Response To Oxidative Stress Cellular Response To Stress Response To Gamma Radiation Response To Activity Response To Cold Response To Cadmium Ion Negative Regulation Of Fat Cell Differentiation Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process
Tagcloud ?