CYP4F12 and HSPA6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYP4F12	HSPA6
Gene Name		cytochrome P450, family 4, subfamily F, polypeptide 12	heat shock 70kDa protein 6 (HSP70B)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Centriole Cytosol COP9 Signalosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Iron Ion Binding Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Leukotriene-B4 20-monooxygenase Activity Aromatase Activity	ATP Binding Enzyme Binding Heat Shock Protein Binding ATPase Activity, Coupled Unfolded Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Xenobiotic Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Blood Coagulation Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Vitamin K Biosynthetic Process Small Molecule Metabolic Process Sodium Ion Homeostasis Oxidation-reduction Process	Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Eicosanoids Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS			Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: HSPA6 SOD2	5 interactors: ADCK5 CISH CYP4F12 DNAJB4 TERF1
Entrez ID		66002	3310
HPRD ID		07102	00775
Ensembl ID		ENSG00000186204	ENSG00000173110
Uniprot IDs		Q9HCS2	P17066
PDB IDs			3FE1
Enriched GO Terms of Interacting Partners?		Response To Temperature Stimulus Erythrophore Differentiation Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Age-dependent Response To Reactive Oxygen Species Response To Magnetism Response To Silicon Dioxide Age-dependent Response To Oxidative Stress Detection Of Oxygen Response To Selenium Ion Oxygen Homeostasis Cellular Response To Ethanol Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Response To L-ascorbic Acid Removal Of Superoxide Radicals Superoxide Anion Generation Cellular Response To Superoxide Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Refolding Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Response To Superoxide Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Immobilization Stress Response To Oxygen Radical Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Abiotic Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Release Of Cytochrome C From Mitochondria Response To Hyperoxia Regulation Of Mitochondrial Membrane Potential Vasodilation Hydrogen Peroxide Metabolic Process Negative Regulation Of Fibroblast Proliferation Superoxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Electrical Stimulus Response To Zinc Ion Negative Regulation Of Blood Pressure Regulation Of Cellular Response To Oxidative Stress Cellular Response To Stress Response To Gamma Radiation Response To Activity Response To Cold Response To Cadmium Ion Negative Regulation Of Fat Cell Differentiation Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process	Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Pressure Natriuresis Age-dependent Telomere Shortening Vitamin K Biosynthetic Process Telomere Maintenance Via Telomere Shortening Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Vitamin K Metabolic Process Negative Regulation Of Transferase Activity Long-chain Fatty Acid Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Epoxygenase P450 Pathway Regulation Of Telomere Maintenance RNA-dependent DNA Replication JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of JAK-STAT Cascade Negative Regulation Of DNA Biosynthetic Process Sodium Ion Homeostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Renal Water Homeostasis Regulation Of Microtubule Polymerization Telomere Maintenance Via Telomere Lengthening Very Long-chain Fatty Acid Metabolic Process Leukotriene Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Quinone Metabolic Process Drug Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Spindle Checkpoint Response To Growth Hormone Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA Replication Negative Regulation Of Catalytic Activity Multicellular Organismal Water Homeostasis
Tagcloud ?			chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa1a hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?			chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa1a hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?