CYP4F12 and HSPA6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CYP4F12	HSPA6
Description		cytochrome P450 family 4 subfamily F member 12	heat shock protein family A (Hsp70) member 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Sodium Ion Homeostasis	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation
Pathways		Fatty acids Eicosanoids	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Glioma ( 34319593) LDL cholesterol levels ( 32203549)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233 28067908) Offspring birth weight ( 31043758) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		5 interacting genes: CFTR HSPA6 MEOX2 SOD2 TIMMDC1	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1
Entrez ID		66002	3310
HPRD ID		07102	00775
Ensembl ID		ENSG00000186204	ENSG00000173110
Uniprot IDs		Q9HCS2	A0A384NKX5 B3KSM6 P17066
PDB IDs			3FE1
Enriched GO Terms of Interacting Partners?		Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Organic Hydroxy Compound Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Somite Specification Response To Magnetism Regulation Of Membrane Hyperpolarization Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Detection Of Oxygen Negative Regulation Of Membrane Hyperpolarization Superoxide Dismutase Activity Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Response To Silicon Dioxide Response To L-ascorbic Acid Ethanolamine Transport Ethanolamine Transmembrane Transporter Activity Positive Regulation Of Tooth Mineralization Cellular Heat Acclimation Response To Superoxide Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Oxygen Radical Choline Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Choline Transport Response To Alcohol ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Intracellular Oxygen Homeostasis Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Response To Selenium Ion Amine Transport Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Response To Manganese Ion	Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization
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