RASL12 and BMPR1B

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		RASL12	BMPR1B
Gene Name		RAS-like, family 12	bone morphogenetic protein receptor, type IB
Image
Gene Ontology Annotations	Cellular Component	Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	GTP Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding
	Biological Process	Small GTPase Mediated Signal Transduction	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways			Signaling by BMP
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 20732626)
Protein-Protein Interactions		9 interactors: ACVR1 APP BMPR1B SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 TGFBR1	63 interactors: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		51285	658
HPRD ID		15217	04457
Ensembl ID		ENSG00000103710	ENSG00000138696
Uniprot IDs		B4DJW2 Q9NYN1	A8KAE3 O00238
PDB IDs		3C5C	3MDY
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta SMAD Protein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Pattern Specification Process Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesoderm Development Primary MiRNA Processing Urogenital System Development Regulation Of Epithelial To Mesenchymal Transition Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Differentiation Mesenchyme Development Growth Heart Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Mesoderm Formation Cell Surface Receptor Signaling Pathway Embryonic Pattern Specification Mesoderm Morphogenesis Regulation Of Binding Regulation Of Cartilage Development Developmental Growth Positive Regulation Of Ossification Embryonic Morphogenesis Cell Fate Commitment Kidney Development Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Renal System Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Production Of MiRNAs Involved In Gene Silencing By MiRNA Mesonephros Development Formation Of Primary Germ Layer Regulation Of Osteoblast Differentiation Anatomical Structure Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition	Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Signaling Regulation Of Protein Phosphorylation Regulation Of Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus SMAD Protein Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Cellular Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Signal Transduction By Phosphorylation Regulation Of Cell Development Regulation Of Cellular Process Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Phosphorylation
Tagcloud ?			125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Difference) ?			125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Intersection) ?