CDK17 and EPHA2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK17	EPHA2
Gene Name		cyclin-dependent kinase 17	EPH receptor A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Protein Phosphorylation Regulation Of Cell Cycle	Skeletal System Development Angiogenesis Vasculogenesis Osteoblast Differentiation Cell Adhesion Multicellular Organismal Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Viral Process Cell Migration Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Activation Of Rac GTPase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs			Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
Diseases
GWAS		Phospholipid levels (plasma) ( 22359512)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		8 interactors: APP EPHA2 PRKACG TDRD7 TGFBR1 YWHAG YWHAQ YWHAZ	30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A
Entrez ID		5128	1969
HPRD ID		09141	01494
Ensembl ID		ENSG00000059758	ENSG00000142627
Uniprot IDs		Q00537	P29317
PDB IDs			1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ
Enriched GO Terms of Interacting Partners?		Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Lens Development In Camera-type Eye Regulation Of Signaling Intracellular Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death System Development Lens Morphogenesis In Camera-type Eye Regulation Of Phosphorus Metabolic Process Response To Wounding Lens Fiber Cell Differentiation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Sexual Reproduction Multicellular Organismal Development Organ Development Anatomical Structure Development Phosphorylation Regulation Of Cellular Component Organization Signal Transduction Camera-type Eye Development Reproduction Developmental Process Regulation Of Protein Phosphorylation Eye Development Positive Regulation Of Organelle Organization Signaling Immune System Process Protein Targeting	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Locomotion Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Neuron Projection Development Cell Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis Neurotrophin Signaling Pathway Neuron Development Cell Morphogenesis Signal Transduction Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Signaling Regulation Of Signaling Cell Communication Fc Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Regulation Of ERBB Signaling Pathway Cell Motility Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Catalytic Activity Neurogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Regulation Of Body Fluid Levels
Tagcloud ?			abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Difference) ?			abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Intersection) ?