CDK17 and BICDL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDK17	BICDL2
Description		cyclin dependent kinase 17	BICD family like cargo adaptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Small GTPase Binding
	Biological Process	Protein Phosphorylation Regulation Of Cell Cycle Phase Transition	Vesicle Transport Along Microtubule Golgi To Secretory Granule Transport
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 30224653) Manganese levels ( 26025379) Phospholipid levels (plasma) ( 22359512)
Interacting Genes		11 interacting genes: APP BICDL2 CDKN2B DPY30 EPHA2 PRKACG TDRD7 TGFBR1 UBC YWHAG YWHAZ	7 interacting genes: API5 CDK17 CFTR KLC3 PKP1 RPL9 TSGA10IP
Entrez ID		5128	146439
HPRD ID		09141	11237
Ensembl ID		ENSG00000059758	ENSG00000162069
Uniprot IDs		Q00537	A1A5D9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Signaling Pathway Response To Nutrient Levels Response To Growth Factor Intracellular Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Animal Organ Development Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Molecular Function Activator Activity Receptor Complex Cellular Response To Nutrient Levels Growth Factor Binding Notochord Cell Development Endothelial Cell Proliferation Vesicle Cellular Response To Glucose Starvation Protein Sequestering Activity Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of ERK1 And ERK2 Cascade TORC1 Signaling Negative Regulation Of TORC1 Signaling Response To Transforming Growth Factor Beta Defense Response To Bacterium Angiogenesis Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Apoptosome Anatomical Structure Formation Involved In Morphogenesis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Hematopoietic Or Lymphoid Organ Development Negative Regulation Of Lymphangiogenesis Notochord Formation	Transepithelial Water Transport Epithelial Fluid Transport Water Transport Fluid Transport Transepithelial Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Desmosome Maintenance Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Intermediate Filament Binding Positive Regulation Of Cytoplasmic Translational Initiation Nuclear Stress Granule Ameloblast Differentiation Intermediate Filament Bundle Assembly Desmosome Assembly Negative Regulation Of Fibroblast Apoptotic Process Sperm Mitochondrial Sheath Assembly Amelogenesis Ciliary Rootlet ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Fibroblast Apoptotic Process
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