PCP4 and CBR3

Data Source: HiPPIP (Novel)

		PCP4	CBR3
Name		Purkinje cell protein 4	carbonyl reductase 3
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Calmodulin Binding	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding
	Biological Process	Positive Regulation Of Neuron Differentiation Positive Regulation Of CAMKK-AMPK Signaling Cascade	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition
Pathways		None	Phase I - Functionalization of compounds
GWAS		Asthma ( 32296059 ) Metabolite levels ( 23823483 ) Systolic blood pressure (alcohol consumption interaction) ( 24376456 ) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 12 weeks) ( 28437668 )	Blood protein levels ( 30072576 ) Lumbar spine bone mineral density ( 22504420 )
Novel Interactors		5 novel interactors: CBR3 DSCAM EMC1 GZMA TTC3	10 novel interactors: ANK1 ATP5PO CLU IL10RB ITSN1 KCNE1 KCNJ15 PCP4 RCAN1 SHOX2
Interacting Genes		7 interacting genes: CALM1 CALML6 DAPK1 PAX6 POT1 TERF1 TERF2IP	7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC
Entrez ID		5121	874
HPRD ID		03378	07222
Ensembl ID		ENSG00000183036	ENSG00000159231
Uniprot IDs		P48539	O75828 V9HW40
PDB IDs		2N77	2HRB
GO Terms Enriched among Interactors		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Endodeoxyribonuclease Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of DNA Metabolic Process Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Deoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly	Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite