PCP4 and TTC3

		PCP4	TTC3
Description		Purkinje cell protein 4	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Calmodulin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Neuron Differentiation Positive Regulation Of CAMKK-AMPK Signaling Cascade	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Asthma ( 32296059) Metabolite levels ( 23823483) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 12 weeks) ( 28437668)	Eye color traits ( 20463881)
Interacting Genes		7 interacting genes: CALM1 CALML6 DAPK1 PAX6 POT1 TERF1 TERF2IP	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		5121	7267
HPRD ID		03378	03773
Ensembl ID		ENSG00000183036	ENSG00000182670
Uniprot IDs		P48539	H7BZ57 P53804
PDB IDs		2N77
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Endodeoxyribonuclease Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of DNA Metabolic Process Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Deoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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