PLCE1 and KIT

Number of citations of the paper that reports this interaction (PMID 12878163)
5

Data Source:
HPRD (in vitro)

		PLCE1	KIT
Gene Name		phospholipase C, epsilon 1	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane	Acrosomal Vesicle Extracellular Space Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Mast Cell Granule
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding Enzyme Binding	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell Growth Phospholipid Metabolic Process Diacylglycerol Biosynthetic Process Regulation Of Smooth Muscle Contraction Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Ras Protein Signal Transduction Heart Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cell Proliferation Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Ras Protein Signal Transduction Inositol Phosphate-mediated Signaling	Activation Of MAPK Activity Ovarian Follicle Development Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Maintenance Signal Transduction By Phosphorylation Lamellipodium Assembly Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Somatic Stem Cell Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Megakaryocyte Development Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Developmental Pigmentation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion
Pathways		Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of KIT signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Adenosine-5\'-Diphosphate Nilotinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Chronic obstructive pulmonary disease ( 21685187) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 21909115) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Hypertension ( 21909115) Personality dimensions ( 21368711) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 21909115)	Bipolar disorder ( 19416921) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		3 interactors: HRAS KIT NRAS	56 interactors: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B TEC YES1
Entrez ID		51196	3815
HPRD ID		07087	01287
Ensembl ID		ENSG00000138193	ENSG00000157404
Uniprot IDs		B7ZM61 Q9P212	P10721
PDB IDs		2BYE 2BYF 2C5L	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Visual Learning Visual Behavior Associative Learning Positive Regulation Of Rac Protein Signal Transduction Learning Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Learning Or Memory Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Cognition Regulation Of Synaptic Transmission Response To Light Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of MAPK Cascade Regulation Of Rac Protein Signal Transduction Response To Radiation Single-organism Behavior Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of Ras Protein Signal Transduction Behavior Chemotaxis Response To Growth Factor Actin Cytoskeleton Organization Regulation Of MAPK Cascade Positive Regulation Of Small GTPase Mediated Signal Transduction Actin Filament-based Process Activation Of MAPKK Activity Lung Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Positive Regulation Of Protein Phosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Immune Response Regulation Of Immune System Process Response To Peptide Hormone Positive Regulation Of Immune System Process Signal Transduction Cellular Response To Organonitrogen Compound Intracellular Signal Transduction Cellular Response To Organic Substance Response To Peptide Regulation Of Body Fluid Levels Response To Organic Substance Immune System Process Signaling Regulation Of Cell Activation Cell Communication Cellular Response To Hormone Stimulus Blood Coagulation Hemostasis Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Signaling Innate Immune Response Regulation Of Cell Adhesion Response To Organonitrogen Compound Regulation Of Lymphocyte Activation Response To Hormone Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Leukocyte Migration Immune Response Response To Wounding Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Activation
Tagcloud ?		accepted adjusting allergic ca2 certain complicated conversion differentiate digestive dual encoded epsilon gtp guanylic isoenzyme make nephrotic overview phospholipase pkc played promotes questions ras rhinitis superfamily th2 transduction upstream	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Difference) ?		accepted adjusting allergic ca2 certain complicated conversion differentiate digestive dual encoded epsilon gtp guanylic isoenzyme make nephrotic overview phospholipase pkc played promotes questions ras rhinitis superfamily th2 transduction upstream	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Intersection) ?