PLCE1

Description		phospholipase C epsilon 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Diacylglycerol Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cataracts ( 34127677) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 21909115 27841878 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Glucose homeostasis traits ( 25524916) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertension ( 31879980 21909115) Language functional connectivity ( 34929384) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27322543 27182965) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 27863252 32888494) Pulse pressure ( 28739976 27841878 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976 21909115 30578418 27841878 27618452) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: GHITM
Interacting Genes		5 interacting genes: HRAS KIT LIMS1 NRAS PPP1R3B
Entrez ID		51196
HPRD ID		07087
Ensembl ID		ENSG00000138193
Uniprot IDs		A0A8I5KXT2 B7ZM61 Q9P212
PDB IDs		2BYE 2BYF 2C5L
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Regulation Of Neuronal Synaptic Plasticity GDP Binding G Protein Activity Regulation Of Long-term Neuronal Synaptic Plasticity Ras Protein Signal Transduction Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly GTPase Complex Calcium:proton Antiporter Activity Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Phospholipase C Activator Activity Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Regulation Of Generation Of Precursor Metabolites And Energy Calcium Export From The Mitochondrion Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mitochondrial Potassium Ion Transmembrane Transport Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Metabolic Process Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Mast Cell Proliferation Mast Cell Proliferation Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Cell Projection Assembly Cell Death Regulation Of Synaptic Plasticity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Oncogene-induced Cell Senescence Negative Regulation Of Programmed Cell Death Programmed Cell Death MAPK Cascade Myeloid Progenitor Cell Differentiation Tongue Development Cell-cell Junction Germ Cell Migration Hematopoietic Stem Cell Migration Regulation Of Mast Cell Proliferation Mast Cell Migration Glycogen Granule Regulation Of Glycogen Catabolic Process
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