SMG5

Gene Name		SMG5 nonsense mediated mRNA decay factor
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase 2A Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		mean corpuscular hemoglobin concentration ( 20139978)
Protein-protein Interactions		7 interactors: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		23381
HPRD ID		16869
Ensembl ID		ENSG00000198952
Uniprot IDs		Q9UPR3
PDB IDs		2HWY
Enriched GO Terms of Interacting Partners?		MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export MRNA Transport RNA Transport Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport Cellular Macromolecule Catabolic Process Gene Expression DNA Metabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Transport Cytoplasmic Transport Nitrogen Compound Metabolic Process RNA Metabolic Process Catabolic Process Establishment Of Localization In Cell Cellular Localization Telomere Maintenance Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Production Of SiRNA Involved In RNA Interference DNA Repair Negative Regulation Of RNA Interference Transcription, RNA-templated Positive Regulation Of Chaperone-mediated Protein Complex Assembly Synaptic Growth At Neuromuscular Junction Regulation Of Dephosphorylation Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression, Epigenetic Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Ubiquitin-dependent SMAD Protein Catabolic Process Telomere Assembly
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