SMG5 and SMG6

Number of citations of the paper that reports this interaction (PMID 12699629)
49

Data Source:
HPRD (in vitro, in vivo)

		SMG5	SMG6
Gene Name		SMG5 nonsense mediated mRNA decay factor	SMG6 nonsense mediated mRNA decay factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex
	Molecular Function	Protein Binding Protein Phosphatase 2A Binding	Endoribonuclease Activity Protein Binding Telomeric DNA Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Telomere Maintenance MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		mean corpuscular hemoglobin concentration ( 20139978)	Aortic root size ( 19584346) Bone mineral density ( 22504420) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Metabolite levels (5-HIAA) ( 23319000)
Protein-Protein Interactions		7 interactors: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1	3 interactors: PPP1CC SMG5 TERT
Entrez ID		23381	23293
HPRD ID		16869	06502
Ensembl ID		ENSG00000198952	ENSG00000070366
Uniprot IDs		Q9UPR3	Q86US8
PDB IDs		2HWY	2DOK 2HWW 2HWX
Enriched GO Terms of Interacting Partners?		MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export MRNA Transport RNA Transport Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport Cellular Macromolecule Catabolic Process Gene Expression DNA Metabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Transport Cytoplasmic Transport Nitrogen Compound Metabolic Process RNA Metabolic Process Catabolic Process Establishment Of Localization In Cell Cellular Localization Telomere Maintenance Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Production Of SiRNA Involved In RNA Interference DNA Repair Negative Regulation Of RNA Interference Transcription, RNA-templated Positive Regulation Of Chaperone-mediated Protein Complex Assembly Synaptic Growth At Neuromuscular Junction Regulation Of Dephosphorylation Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression, Epigenetic Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Ubiquitin-dependent SMAD Protein Catabolic Process Telomere Assembly	Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Telomere Assembly Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference RNA Interference Replicative Senescence Triglyceride Catabolic Process RNA-dependent DNA Replication Regulation Of Gene Silencing Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cellular Response To DsRNA Posttranscriptional Gene Silencing Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Glycogen Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing By RNA MRNA Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Response To DsRNA RNA Export From Nucleus Telomere Maintenance Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Triglyceride Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Circadian Rhythm Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Nuclear Export MRNA Transport Regulation Of Dephosphorylation Catabolic Process
Tagcloud ?			atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms
Tagcloud (Difference) ?			atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms
Tagcloud (Intersection) ?