SMG5 and SMG7

Number of citations of the paper that reports this interaction (PubMedID 14636577)
0

Data Source:
HPRD (in vivo)

		SMG5	SMG7
Description		SMG5 nonsense mediated mRNA decay factor	SMG7 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 29403010)	Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 26502338 27399966 28714469)
Interacting Genes		8 interacting genes: APP BTG3 SMG1 SMG6 SMG7 STUB1 TERT UPF1	7 interacting genes: FGFR3 GSK3A GSK3B MDM2 RAD17 SIRPA SMG5
Entrez ID		23381	9887
HPRD ID		16869	10723
Ensembl ID		ENSG00000198952	ENSG00000116698
Uniprot IDs		Q9UPR3	A0A8I5KSL3 A0A8I5KYV3 E9PD50 Q6TV06 Q92540
PDB IDs		2HWY	1YA0
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus RNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport Telomerase RNA Binding Telomerase Holoenzyme Complex Nuclear-transcribed MRNA Catabolic Process Nuclear Export MRNA Transport MRNA Catabolic Process RNA Transport RNA Catabolic Process Nucleobase-containing Compound Transport Intracellular Transport Protein-folding Chaperone Binding Regulation Of Telomere Maintenance Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Cellular Localization Establishment Of Localization In Cell Regulation Of Dephosphorylation Chromosome, Telomeric Region Cytoplasm Macromolecule Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Response To Endoplasmic Reticulum Stress MRNA Metabolic Process Regulation Of Chromosome Organization Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Metabolic Process TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Metabolic Process G Protein-coupled Receptor Binding Regulation Of MiRNA Transcription Nucleus Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Response To Interleukin-1	Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Proteasomal Protein Catabolic Process Protein Kinase A Catalytic Subunit Binding Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Tau-protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heart Valve Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Phosphorus Metabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Biosynthetic Process Regulation Of Protein Export From Nucleus Regulation Of Glycogen Metabolic Process Tau Protein Binding Negative Regulation Of Cell Development Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Cell Adhesion Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Developmental Growth
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