TUBD1 and GJB3

Data Source: HiPPIP (Novel)

		TUBD1	GJB3
Name		tubulin delta 1	gap junction protein beta 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Cell Projection	Cytoplasm Plasma Membrane Cell-cell Junction Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway	Placenta Development Cell Communication Cell-cell Signaling Transmembrane Transport
Pathways		None	Gap junction assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Vinblastine	None
Diseases		None	Deafness, autosomal recessive Erythrokeratodermia variabilis Deafness, autosomal dominant
GWAS		C-reactive protein levels ( 30388399 ) Chronotype ( 30696823 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 23128233 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 29403010 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Systolic blood pressure ( 30578418 )	Intraocular pressure ( 30591961 ) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883 )
Interacting Genes		1 interacting genes: TOP1	15 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1
Entrez ID		51174	2707
HPRD ID		06297	04505
Ensembl ID		ENSG00000108423	ENSG00000188910
Uniprot IDs		Q9UJT1	O75712
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Purine-containing Compound DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Cellular Response To Luteinizing Hormone Stimulus Dense Fibrillar Component Response To Temperature Stimulus Detection Of Temperature Stimulus Involved In Thermoception Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Fever Generation Temperature-gated Ion Channel Activity Smooth Muscle Contraction Involved In Micturition Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Thermoception Response To Capsazepine Lactoperoxidase Activity Defense Response To Nematode Peptidyl-tRNA Hydrolase Activity	None