TUBD1 and TRPV1

Data Source: HiPPIP (Novel)

		TUBD1	TRPV1
Name		tubulin delta 1	transient receptor potential cation channel subfamily V member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Cell Projection	Plasma Membrane Membrane Dendritic Spine Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Nucleotide Binding Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Metal Ion Binding Phosphoprotein Binding Temperature-gated Ion Channel Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Fever Generation Diet Induced Thermogenesis Peptide Secretion Lipid Metabolic Process Monoatomic Ion Transport Calcium Ion Transport Cell Surface Receptor Signaling Pathway Chemosensory Behavior Response To PH Response To Heat Urinary Bladder Smooth Muscle Contraction Sensory Perception Of Pain Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Cellular Response To Heat Response To Pain Behavioral Response To Pain Sensory Perception Of Taste Sensory Perception Of Mechanical Stimulus Thermoception Detection Of Temperature Stimulus Involved In Thermoception Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Protein Homotetramerization Transmembrane Transport Excitatory Postsynaptic Potential Smooth Muscle Contraction Involved In Micturition Calcium Ion Transmembrane Transport Cellular Response To Alkaloid Cellular Response To ATP Cellular Response To Acidic PH Calcium Ion Import Across Plasma Membrane Response To Capsazepine Calcium Ion Import Into Cytosol
Pathways		None	TRP channels
Drugs		Vinblastine	alpha-Linolenic acid Icosapent Aspartame Tramadol Acetaminophen Camphor Ricinoleic acid Resiniferatoxin Capsaicin Cannabidiol Zucapsaicin Propacetamol Capsicum oleoresin Nonivamide (S)-camphor Medical Cannabis Nabiximols Cannabidivarin
GWAS		C-reactive protein levels ( 30388399 ) Chronotype ( 30696823 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 23128233 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 29403010 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Systolic blood pressure ( 30578418 )	No GWAS studies recorded
Interacting Genes		1 interacting genes: TOP1	8 interacting genes: AKAP5 CALM1 EGFR ITCH PRKCE SNAPIN SYT9 TRPV2
Entrez ID		51174	7442
HPRD ID		06297	03648
Ensembl ID		ENSG00000108423	ENSG00000196689
Uniprot IDs		Q9UJT1	Q8NER1
PDB IDs		Not available	6L93 8GF8 8GF9 8GFA 8JQR 8X94 8YCP
GO Terms Enriched among Interactors		Response To Purine-containing Compound DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Cellular Response To Luteinizing Hormone Stimulus Dense Fibrillar Component Response To Temperature Stimulus Detection Of Temperature Stimulus Involved In Thermoception Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Fever Generation Temperature-gated Ion Channel Activity Smooth Muscle Contraction Involved In Micturition Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Thermoception Response To Capsazepine Lactoperoxidase Activity Defense Response To Nematode Peptidyl-tRNA Hydrolase Activity	Regulation Of Calcium Ion Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Metal Ion Transport Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transport Regulation Of Transport Synaptic Vesicle Membrane Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Periphery Modulation Of Chemical Synaptic Transmission Regulation Of Protein Localization To Membrane Positive Regulation Of Calcium Ion Import Calcineurin-mediated Signaling Regulation Of Cellular Localization Cell-cell Signaling Signaling Cell Communication Regulation Of Calcium Ion Import Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Cellular Component Organization Multivesicular Body, Internal Vesicle Lumen Positive Regulation Of Late Endosome To Lysosome Transport SNARE Binding Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Cation Transmembrane Transport Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle-mediated Transport In Synapse Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling Regulation Of Cell Growth Shc-EGFR Complex Synapse