TUBD1 and TMED1

Data Source: HiPPIP (Novel)

		TUBD1	TMED1
Name		tubulin delta 1	transmembrane p24 trafficking protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway	Immune System Process Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Signal Transduction Cell-cell Signaling Protein Transport Innate Immune Response
Drugs		Vinblastine	None
GWAS		C-reactive protein levels ( 30388399 ) Chronotype ( 30696823 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 23128233 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 29403010 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Systolic blood pressure ( 30578418 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: EPX GJB3 PTRH2 RFX5 TMED1 TRPV1	1 novel interactors: TUBD1
Interacting Genes		1 interacting genes: TOP1	6 interacting genes: F2RL1 GPR37 IL1RL1 LTB4R2 SEC23B SMAD3
Entrez ID		51174	11018
HPRD ID		06297	05653
Ensembl ID		ENSG00000108423	ENSG00000099203
Uniprot IDs		Q9UJT1	Q13445
PDB IDs		Not available	7RRM
GO Terms Enriched among Interactors		Response To Purine-containing Compound DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Cellular Response To Luteinizing Hormone Stimulus Dense Fibrillar Component Response To Temperature Stimulus Detection Of Temperature Stimulus Involved In Thermoception Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Fever Generation Temperature-gated Ion Channel Activity Smooth Muscle Contraction Involved In Micturition Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Thermoception Response To Capsazepine Lactoperoxidase Activity Defense Response To Nematode Peptidyl-tRNA Hydrolase Activity	Positive Regulation Of Positive Chemotaxis Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Interleukin-1 Beta Production Neuropeptide Signaling Pathway Prosaposin Receptor Activity G Protein-coupled Peptide Receptor Activity Sterol Response Element Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Ameboidal-type Cell Migration Paraxial Mesoderm Morphogenesis Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Interleukin-33 Binding Interleukin-33 Receptor Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Regulation Of Wound Healing Positive Regulation Of Chemotaxis Myeloid Leukocyte Differentiation Positive Regulation Of Killing Of Cells Of Another Organism Regulation Of Lung Blood Pressure Leukotriene Signaling Pathway Cell-cell Junction Organization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytoskeleton Organization Mature Conventional Dendritic Cell Differentiation Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Signal Transduction Regulation Of Response To Wounding Regulation Of Blood Pressure Thrombin-activated Receptor Activity Positive Regulation Of Dopamine Metabolic Process Pericardium Development Mesoderm Morphogenesis