NAA20 and IKBKB

Number of citations of the paper that reports this interaction (PubMedID 19716809)
20

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		NAA20	IKBKB
Description		N-alpha-acetyltransferase 20, NatB catalytic subunit	inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol NatB Complex	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein N-terminal-methionine Acetyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Transferrin Receptor Binding
	Biological Process	N-terminal Protein Amino Acid Acetylation N-terminal Peptidyl-aspartic Acid Acetylation N-terminal Peptidyl-glutamine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Regulation Of Actin Cytoskeleton Organization	Protein Polyubiquitination Pattern Recognition Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Maturation Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly
Pathways			Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes
Drugs			Mesalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases
GWAS
Interacting Genes		2 interacting genes: ADIPOR1 IKBKB	91 interacting genes: ACVR1 AKT1 AURKA BTRC CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 COPS5 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HMGCL HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH MYC NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR ROCK1 SAMHD1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB
Entrez ID		51126	3551
HPRD ID		07136	04462
Ensembl ID		ENSG00000173418	ENSG00000104365
Uniprot IDs		A8MZB2 P61599	A0A499FJS7 G3V105 O14920
PDB IDs		6VP9 7STX 8G0L	3BRT 3BRV 4E3C 4KIK 8OMV
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Protein Kinase Binding CD40 Receptor Complex Transferrin Receptor Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent TRIF-dependent Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I IkappaB Kinase Activity Negative Regulation Of Bicellular Tight Junction Assembly IkappaB Kinase Complex Adiponectin Binding Adipokinetic Hormone Receptor Activity Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Bicellular Tight Junction Assembly MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Endothelial Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Receptor Signaling Pathway Via STAT Antigen Processing And Presentation Of Exogenous Antigen Toll-like Receptor Signaling Pathway Fc Receptor Signaling Pathway Negative Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway	Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Signal Transduction Protein Modification Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Protein Serine/threonine Kinase Activity Response To Stress Intracellular Signaling Cassette Macromolecule Metabolic Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Enzyme Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Gene Expression Positive Regulation Of Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Protein Serine Kinase Activity
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