RDH11 and ROBO2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RDH11	ROBO2
Gene Name		retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	roundabout, axon guidance receptor, homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Intracellular Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome
	Molecular Function	Retinol Dehydrogenase Activity NADP-retinol Dehydrogenase Activity	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Phototransduction, Visible Light Adaptation Of Rhodopsin Mediated Signaling Retinol Metabolic Process Retinal Metabolic Process Oxidation-reduction Process	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis
Pathways		Visual phototransduction Signaling by Retinoic Acid The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction RA biosynthesis pathway Retinoid metabolism and transport	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor
Drugs
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		3 interactors: BLOC1S2 CA12 ROBO2	16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4
Entrez ID		51109	6092
HPRD ID		09707	11895
Ensembl ID		ENSG00000072042	ENSG00000185008
Uniprot IDs		Q8TC12	Q9HCK4
PDB IDs			1UEM 1UJT 2EDJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Negative Chemotaxis Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Luteolysis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Chloride Ion Homeostasis Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Olfactory Bulb Interneuron Differentiation Negative Regulation Of Synapse Assembly Positive Regulation Of Mitochondrial Membrane Permeability Anterograde Synaptic Vesicle Transport Microtubule Nucleation Retinal Ganglion Cell Axon Guidance Melanosome Organization Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Microtubule Polymerization Negative Regulation Of Chemotaxis Neuron Projection Development Anterograde Axon Cargo Transport Apoptotic Process Involved In Development Bicarbonate Transport Regulation Of Mitochondrial Membrane Permeability Forebrain Neuron Development Neuron Recognition Regulation Of Membrane Permeability Neuron Development Apoptotic Process Secretory Granule Organization Microtubule Polymerization Or Depolymerization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Olfactory Bulb Development Programmed Cell Death One-carbon Metabolic Process Olfactory Lobe Development Anion Homeostasis Cell Death Death Axon Cargo Transport Neuron Differentiation Cell Projection Organization Regulation Of Synapse Assembly Cellular Pigmentation Mitochondrial Membrane Organization Forebrain Neuron Differentiation Apoptotic Mitochondrial Changes	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death
Tagcloud ?			arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?			arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?