RDH11 and ROBO2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RDH11	ROBO2
Description		retinol dehydrogenase 11	roundabout guidance receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Aldehyde Dehydrogenase (NADP+) Activity All-trans-retinol Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Retinol Metabolic Process Retinal Metabolic Process Cellular Detoxification Of Aldehyde	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Retinoid metabolism and transport	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud
Drugs		Vitamin A
Diseases			Vesicoureteral reflux
GWAS			Bell's palsy ( 33602968) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		5 interacting genes: BLOC1S2 CA12 ROBO2 SELENOF TMEM31	18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4
Entrez ID		51109	6092
HPRD ID		09707	11895
Ensembl ID		ENSG00000072042	ENSG00000185008
Uniprot IDs		A0A0S2Z583 Q8TC12	A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4
PDB IDs			1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?		Chloride Ion Homeostasis Estrous Cycle Carbonate Dehydratase Activity Ovulation Cycle Negative Regulation Of Negative Chemotaxis Olfactory Bulb Interneuron Development Endocardial Cushion Formation Apoptotic Process Involved In Luteolysis Heart Induction Axon Guidance Receptor Activity Negative Regulation Of Synapse Organization Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Axon Choice Point Recognition Negative Regulation Of Synapse Assembly Pulmonary Valve Morphogenesis Regulation Of Heart Morphogenesis Axolemma Selenium Binding Sperm DNA Condensation 'de Novo' Post-translational Protein Folding 'de Novo' Protein Folding Thioredoxin Peroxidase Activity Anterograde Synaptic Vesicle Transport Gamma-tubulin Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane Regulation Of Lysosome Size Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Regulation Of Vesicle Size BORC Complex BLOC-1 Complex Mitochondrial Outer Membrane Permeabilization Monoatomic Anion Homeostasis Retinal Ganglion Cell Axon Guidance Forebrain Neuron Development Organ Induction Platelet Dense Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Neuron Projection Development Outflow Tract Septum Morphogenesis Positive Regulation Of Mitochondrial Membrane Permeability	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis
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