TMED10 and COPA

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TMED10	COPA
Description		transmembrane p24 trafficking protein 10	coat protein complex I subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Growth Cone COPI-coated Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Syntaxin Binding	MRNA Binding Hormone Activity Structural Molecule Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Vesicle-mediated Transport Positive Regulation Of Interleukin-1 Production Vesicle Cargo Loading COPI-coated Vesicle Budding Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Positive Regulation Of Protein Secretion Protein Transmembrane Transport Protein Localization To ERGIC Cytosol To ERGIC Protein Transport Regulation Of Amyloid-beta Formation	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Protein Transport Vesicle-mediated Transport Pancreatic Juice Secretion Protein Localization To Axon Protein Localization To Cell Leading Edge
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254) Heel bone mineral density ( 30598549) Height ( 19343178) Refractive error ( 32231278)	Breast size ( 27182965)
Interacting Genes		20 interacting genes: APH1A ARCN1 ARF1 CDC42 CEBPA COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 NCSTN NPSR1 PSENEN SEC23B SLC13A1 TMED2	21 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 HUNK MTNR1B PDGFRB PTEN RBM11 RUNX1 SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2
Entrez ID		10972	1314
HPRD ID		12013	03564
Ensembl ID		ENSG00000170348	ENSG00000122218
Uniprot IDs		A0A024R6I3 P49755	P53621
PDB IDs			6PBG 6TZT 6U3V
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Membrane COPI Vesicle Coat Golgi Membrane Transport Vesicle COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Membrane Coat Endoplasmic Reticulum Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Transport Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Protein Transport Gamma-secretase Complex Structural Molecule Activity Notch Receptor Processing Amyloid-beta Formation Intracellular Protein Localization Membrane Protein Intracellular Domain Proteolysis Golgi Localization Amyloid Precursor Protein Catabolic Process Endopeptidase Activator Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Membrane Membrane Protein Proteolysis Notch Signaling Pathway Establishment Of Golgi Localization Endoplasmic Reticulum Golgi Cisterna Membrane Protein Localization To Axon Organelle Transport Along Microtubule Embryonic Placenta Development Protein Secretion Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Presynaptic Membrane Vesicle Cargo Loading Dendritic Spine Organization Mitotic Cleavage Furrow Ingression RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding	COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Membrane Golgi Vesicle Transport Golgi Apparatus COPI Coating Of Golgi Vesicle Establishment Of Protein Localization Golgi Localization Intracellular Protein Localization Phosphatidylinositol-3-phosphate Phosphatase Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum Membrane Cell Migration Involved In Heart Development Zymogen Granule Membrane Protein Transport Dendritic Spine Morphogenesis Cytoplasmic Vesicle Intracellular Transport Intracellular Protein Transport Golgi Organization Phosphatidylinositol Dephosphorylation COPII Vesicle Coating Vesicle Cargo Loading Dendritic Spine Organization Intra-Golgi Vesicle-mediated Transport Membrane Organization Phospholipid Dephosphorylation COPII-coated ER To Golgi Transport Vesicle Vesicle Coating Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Negative Regulation Of Synaptic Vesicle Clustering Oxoglutarate:malate Antiporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Neuron Projection Organization Postsynapse Organization Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Syntaxin Binding Cerebellar Purkinje Cell Layer Maturation GBD Domain Binding Storage Vacuole
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