SH3GLB1 and ABHD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3GLB1	ABHD5
Description		SH3 domain containing GRB2 like, endophilin B1	abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Membrane Nuclear Body Midbody Cytoplasmic Vesicle Protein-containing Complex	Nucleoplasm Cytoplasm Lipid Droplet Cytosol
	Molecular Function	Fatty Acid Binding Protein Binding Lipid Binding Lysophosphatidic Acid Acyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Phosphatidylinositol 3-kinase Activator Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Triacylglycerol Lipase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity Lipase Activator Activity
	Biological Process	Phosphatidic Acid Biosynthetic Process Autophagy Apoptotic Process Phospholipid Biosynthetic Process Positive Regulation Of Autophagy Regulation Of Macroautophagy Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Autophagic Cell Death 'de Novo' Post-translational Protein Folding Membrane Organization Membrane Fission Positive Regulation Of Membrane Tubulation Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Vacuolar Membrane Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Autophagosome Assembly	Lipid Metabolic Process Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis
Pathways			Triglyceride catabolism
Drugs
Diseases			Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS			A body shape index ( 34021172) General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		52 interacting genes: ABHD5 ADAM15 ADAM9 AGTRAP AMPH APP ARFIP2 ARHGAP17 BAX BIN1 C1D CACFD1 CDKN2D CMTM5 COQ8A DESI2 DNM2 EXOSC5 F8A1 FAM114A2 FN1 FUNDC1 GADD45A GADD45G GSTP1 HTATIP2 HTT IRGM ITGB1BP2 MAL2 MTA1 PSMA1 RABAC1 RABGGTB RHEX RIC8A SH3GLB2 SH3KBP1 SIN3A SMIM5 SNX1 SNX4 SYNGR3 SYNJ1 SYP TAX1BP1 TFIP11 TPD52 TPD52L2 TTN UBL7 ZNF576	21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12
Entrez ID		51100	51099
HPRD ID		15333	11986
Ensembl ID		ENSG00000097033	ENSG00000011198
Uniprot IDs		A0A087WW40 A0A140VJU5 A0A994J549 Q9Y371	A0A0S2Z5D6 A0A2U3TZT9 C9J1D1 Q8WTS1
PDB IDs		6UP6 6UPN 9G2R 9G2U 9G2W
Enriched GO Terms of Interacting Partners?		Cytoplasmic Vesicle Protein Binding SH3 Domain Binding Synaptic Vesicle Vesicle-mediated Transport Insulin Receptor Binding Leptin Receptor Binding Endocytosis Integrin Binding BH3 Domain Binding Cytoplasm Synaptic Vesicle Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Positive Regulation Of Programmed Cell Death Peptidase Activator Activity Positive Regulation Of Catabolic Process Establishment Of Vesicle Localization	Lipid Droplet Disassembly Lipid Droplet Positive Regulation Of Triglyceride Storage Acylglycerol Acyl-chain Remodeling Lipid Storage Lipid Droplet Organization Regulation Of Lipid Storage Cellular Response To Glucose Starvation Organelle Disassembly Positive Regulation Of Lipid Storage Glycerolipid Metabolic Process ADP Binding Protein Localization To Vacuolar Membrane Cellular Response To Starvation Response To Starvation Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity
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