SH3GLB1 and AMPH

Number of citations: 0 (PubMedID 12456676)
Data Source: HPRD (in vitro)

		SH3GLB1	AMPH
Name		SH3 domain containing GRB2 like, endophilin B1	amphiphysin
Structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Membrane Nuclear Body Midbody Cytoplasmic Vesicle Protein-containing Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Synaptic Vesicle Membrane Leading Edge Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Fatty Acid Binding Protein Binding Lipid Binding Lysophosphatidic Acid Acyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Phosphatidylinositol 3-kinase Activator Activity	Protein Binding Phospholipid Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Autophagy Apoptotic Process Phospholipid Biosynthetic Process Positive Regulation Of Autophagy Regulation Of Macroautophagy Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Autophagic Cell Death 'de Novo' Post-translational Protein Folding Membrane Organization Membrane Fission Positive Regulation Of Membrane Tubulation Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Vacuolar Membrane Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Autophagosome Assembly	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis
Pathways		None	Clathrin-mediated endocytosis
GWAS		No GWAS studies recorded	Ankylosing spondylitis ( 30946743 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Cerebral microbleeds ( 31209788 ) Post bronchodilator FEV1 ( 26634245 )
Interacting Genes		52 interacting genes: ABHD5 ADAM15 ADAM9 AGTRAP AMPH APP ARFIP2 ARHGAP17 BAX BIN1 C1D CACFD1 CDKN2D CMTM5 COQ8A DESI2 DNM2 EXOSC5 F8A1 FAM114A2 FN1 FUNDC1 GADD45A GADD45G GSTP1 HTATIP2 HTT IRGM ITGB1BP2 MAL2 MTA1 PSMA1 RABAC1 RABGGTB RHEX RIC8A SH3GLB2 SH3KBP1 SIN3A SMIM5 SNX1 SNX4 SYNGR3 SYNJ1 SYP TAX1BP1 TFIP11 TPD52 TPD52L2 TTN UBL7 ZNF576	29 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A EGFR ITSN2 KHDRBS1 LGMN MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN
Entrez ID		51100	273
HPRD ID		15333	02687
Ensembl ID		ENSG00000097033	ENSG00000078053
Uniprot IDs		A0A087WW40 A0A140VJU5 A0A994J549 Q9Y371	P49418
PDB IDs		6UP6 6UPN 9G2R 9G2U 9G2W	1KY7 1UTC 3SOG 4ATM 5M5S 5M61
GO Terms Enriched among Interactors		Cytoplasmic Vesicle Protein Binding SH3 Domain Binding Synaptic Vesicle Vesicle-mediated Transport Insulin Receptor Binding Leptin Receptor Binding Endocytosis Integrin Binding BH3 Domain Binding Cytoplasm Synaptic Vesicle Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Positive Regulation Of Programmed Cell Death Peptidase Activator Activity Positive Regulation Of Catabolic Process Establishment Of Vesicle Localization	Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Presynapse Synaptic Vesicle Endocytosis Endocytosis Import Into Cell Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Pit Receptor-mediated Endocytosis Establishment Of Localization In Cell Tau Protein Binding Vesicle Scission Regulation Of Vesicle-mediated Transport Receptor Catabolic Process Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Negative Regulation Of Macromolecule Metabolic Process Protein Kinase 5 Complex Protein Polymerization Protein Kinase Binding Positive Regulation Of Cellular Component Organization Cytosol Regulation Of Developmental Growth Negative Regulation Of Metabolic Process Identical Protein Binding Clathrin-dependent Endocytosis Positive Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Assembly Microtubule Negative Regulation Of ERBB Signaling Pathway Clathrin Coat Disassembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Calmodulin-dependent Protein Phosphatase Activity Synaptic Vesicle Transport Negative Regulation Of Calcium Ion Transmembrane Transport Vesicle Uncoating Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of DNA Replication Axon Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Vesicle Localization Clathrin Coat Of Coated Pit Regulation Of Growth Membrane Fission Cell Projection Organization Cytoplasmic Vesicle