DERL2 and FXYD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DERL2	FXYD6
Description		derlin 2	FXYD domain containing ion transport regulator 6
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding	Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process	Suckling Behavior Response To Unfolded Protein Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Growth Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		12 interacting genes: DIABLO FXYD6 KRTAP10-3 KRTAP10-7 KRTAP10-8 LMNA MELTF MPP1 PTPN9 RBFA SERPINA1 SFT2D1	67 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35E1 SLC35E3 SLC35H1 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119
Entrez ID		51009	53826
HPRD ID		16796	09456
Ensembl ID		ENSG00000072849	ENSG00000137726
Uniprot IDs		I3L3R8 Q9GZP9	Q9H0Q3
PDB IDs			8D3U 8D3V 8D3W 8D3X 8D3Y
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Membrane Transmembrane Transport Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Antiporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Monoatomic Ion Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid
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