DERL2 and MELTF

Number of citations of the paper that reports this interaction (PubMedID 16449192)
66

Data Source:
HPRD (in vivo)

		DERL2	MELTF
Description		derlin 2	melanotransferrin
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Membrane Recycling Endosome Extracellular Exosome Side Of Membrane
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding	Iron Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Suckling Behavior Response To Unfolded Protein Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Growth Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Regulation Of Cell Growth Monoatomic Ion Transport Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655)	Malaria ( 31844061)
Interacting Genes		12 interacting genes: DIABLO FXYD6 KRTAP10-3 KRTAP10-7 KRTAP10-8 LMNA MELTF MPP1 PTPN9 RBFA SERPINA1 SFT2D1	11 interacting genes: CFTR CYSRT1 DERL1 DERL2 DERL3 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA
Entrez ID		51009	4241
HPRD ID		16796	01122
Ensembl ID		ENSG00000072849	ENSG00000163975
Uniprot IDs		I3L3R8 Q9GZP9	P08582 Q53XS6
PDB IDs			6XR0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Signal Recognition Particle Binding Response To Endoplasmic Reticulum Stress Regulation Of Cellular Localization Negative Regulation Of Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol ERAD Pathway Regulation Of Retrograde Protein Transport, ER To Cytosol Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Negative Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Protein Destabilization Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Early Endosome Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Derlin-1-VIMP Complex Response To Unfolded Protein Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Protein-containing Complex Binding Keratin Filament
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?