SPOCK3 and MMP14

Number of citations of the paper that reports this interaction (PubMedID 11751414)
0

Data Source:
HPRD (in vivo)

		SPOCK3	MMP14
Description		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3	matrix metallopeptidase 14
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton
	Molecular Function	Enzyme Inhibitor Activity Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Motility	Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Cell Migration Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Bone Development Cellular Response To Genistein Craniofacial Suture Morphogenesis GDF15-GFRAL Signaling Pathway Negative Regulation Of GDF15-GFRAL Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant
Pathways		Activation of Matrix Metalloproteinases	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Marimastat
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive function ( 28808816) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Immune reponse to smallpox (secreted IL-10) ( 22610502) Medial orbital frontal cortex volume ( 31530798) Obesity-related traits ( 23251661) Total antioxidant status in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Verbal declarative memory ( 25648963) Weight ( 28552196)	Appendicular lean mass ( 33097823) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 28869591 30598549) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: CREB3 MMP14 MMP3 SPOCK2	44 interacting genes: ACAN ACE2 ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CCN2 CCN5 CLDN1 CORO1C CXCL8 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SLPI SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 TNF TNFRSF21 ZUP1
Entrez ID		50859	4323
HPRD ID		12147	02856
Ensembl ID		ENSG00000196104	ENSG00000157227
Uniprot IDs		A0A0A0MTJ2 B4DI52 Q9BQ16	P50281
PDB IDs			1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Extracellular Matrix Organization Regulation Of Locomotion Extracellular Structure Organization Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Locomotion Cellular Response To Genistein Positive Regulation Of Cell Motility Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Deacetylase Activity Metallopeptidase Activity Serine-type Endopeptidase Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Migration Response To Odorant Response To Genistein Regulation Of Cell-substrate Adhesion Regulation Of Leukocyte Migration GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Release From Viral Latency Astrocyte Cell Migration CCR1 Chemokine Receptor Binding Response To Phenylpropanoid Negative Regulation Of Signal Transduction Cellular Response To UV-A Extracellular Space CAMP Response Element Binding Protein Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Oxidative Stress Cellular Response To Stress Response To UV-A Chondrocyte Proliferation Positive Regulation Of Myotube Differentiation Regulation Of Cell Growth Metalloendopeptidase Inhibitor Activity Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Induction Of Positive Chemotaxis Cellular Response To Nitric Oxide Peptidase Activity Cellular Response To Reactive Nitrogen Species	Extracellular Matrix Extracellular Space Extracellular Region Metalloendopeptidase Inhibitor Activity Regulation Of Membrane Protein Ectodomain Proteolysis Enzyme Inhibitor Activity Regulation Of Entry Of Bacterium Into Host Cell Symbiont Entry Into Host Cell Response To Amyloid-beta Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cell Motility Regulation Of Locomotion Biological Process Involved In Interaction With Host Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Endopeptidase Activity Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Proteolysis Regulation Of Transcytosis Extracellular Matrix Disassembly Peptidase Inhibitor Activity Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Endocytosis Membrane Raft Positive Regulation Of Locomotion Collagen Binding Collagen Metabolic Process Regulation Of Viral Process Leukocyte Migration Regulation Of Bicellular Tight Junction Assembly Apoptotic Cell Clearance Negative Regulation Of Proteolysis Viral Translation Viral Life Cycle Regulation Of Protein Catabolic Process Serine-type Endopeptidase Activity Regulation Of Multicellular Organismal Process Humoral Immune Response Heparin Binding Cell Motility Regulation Of Cell Junction Assembly Virus Receptor Activity Extracellular Matrix Binding Response To Cytokine Response To Peptide Receptor-mediated Endocytosis
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