SPOCK3 and MMP14

Number of citations of the paper that reports this interaction (PMID 11751414)
21

Data Source:
HPRD (in vivo)

		SPOCK3	MMP14
Gene Name		sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	matrix metallopeptidase 14 (membrane-inserted)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome
	Molecular Function	Calcium Ion Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity
	Biological Process	Signal Transduction Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-10) ( 22610502) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: MMP14 MMP3 SPOCK2	23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4
Entrez ID		50859	4323
HPRD ID		12147	02856
Ensembl ID		ENSG00000196104	ENSG00000157227
Uniprot IDs		B4DI52 B4DJY3 Q9BQ16	P50281
PDB IDs			1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Oxidative Stress-induced Cell Death Astrocyte Cell Migration Response To Oxidative Stress Chondrocyte Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Cellular Response To Nitric Oxide Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Regulation Of Cell Migration Response To Nitric Oxide Regulation Of Cell Adhesion Craniofacial Suture Morphogenesis Regulation Of Cell Motility Endothelial Cell Proliferation Positive Regulation Of Protein Oligomerization Regulation Of Locomotion Negative Regulation Of Focal Adhesion Assembly Regulation Of Cellular Component Movement Cellular Response To Reactive Nitrogen Species Regulation Of Protein Oligomerization Endodermal Cell Differentiation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase B Signaling Endochondral Ossification Negative Regulation Of Reactive Oxygen Species Metabolic Process Peptide Cross-linking Regulation Of Focal Adhesion Assembly Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Cell-substrate Adhesion Endoderm Formation Chondroitin Sulfate Metabolic Process Regulation Of Cell Junction Assembly Cellular Response To Amino Acid Stimulus Glial Cell Migration Embryonic Cranial Skeleton Morphogenesis Ovarian Follicle Development Synapse Assembly Endochondral Bone Morphogenesis Endoderm Development Epithelial Cell Proliferation Proteolysis Ovulation Cycle Process	Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process
Tagcloud ?			5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?			5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Intersection) ?