SPOCK3 and CREB3

Number of citations: 20 (PubMedID 21516116)
Data Source: BioGRID (two hybrid)

		SPOCK3	CREB3
Name		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3	cAMP responsive element binding protein 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Body Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Enzyme Inhibitor Activity Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding CCR1 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Motility	Regulation Of Cell Growth DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Chemotaxis Response To Unfolded Protein Release From Viral Latency Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Induction Of Positive Chemotaxis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity Integrated Stress Response Signaling Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of Matrix Metalloproteinases	CREB3 factors activate genes CREB3 factors activate genes
GWAS		Blood protein levels ( 30072576 ) Cognitive function ( 28808816 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Immune reponse to smallpox (secreted IL-10) ( 22610502 ) Medial orbital frontal cortex volume ( 31530798 ) Obesity-related traits ( 23251661 ) Total antioxidant status in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Verbal declarative memory ( 25648963 ) Weight ( 28552196 )	Brain morphology (MOSTest) ( 32665545 )
Novel Interactors		None recorded	1 novel interactors: TIMM10
Interacting Genes		4 interacting genes: CREB3 MMP14 MMP3 SPOCK2	205 interacting genes: ABHD16A ACKR2 ACSF2 ACSL5 ADTRP AGER AGPAT3 ALG3 ALG8 APH1A APOA2 APOD APPBP2 AQP1 AQP2 AQP4 AQP5 ATF3 ATF4 ATP6AP2 ATP6V0C BCAP29 BCAT2 BCL2L1 BIK BNIP2 BNIP3 BTN2A2 C2 C3orf52 CACFD1 CCR1 CD207 CD82 CDS2 CEBPG CELA3A CES1 CFHR5 CGRRF1 CHMP7 CLCN7 CLDN19 CLDND2 CLP1 CMTM5 CNPY3 CREB3L1 CREB3L3 CT45A5 CTSW CYB561 CYB5B CYBC1 CYBRD1 CYP4F2 DDIT3 DNAJC30 DOLK DRAM1 EBP EMC6 EMD ERG28 FA2H FAM3A FAM3C FDFT1 FDPS FIS1 FMO1 FMO3 FXYD3 FXYD6 GJA1 GJB2 GYPA HCFC1 HDAC3 HMOX1 HVCN1 ICAM4 IGFBP5 ITM2B JUN KCNK1 KLHL30-AS1 KRTCAP2 LAT LHFPL5 LILRB5 LMBR1L LMNA LPCAT2 LTA MAL2 MALL MARCHF5 MFSD11 MGST2 MRPL57 MS4A1 MYADM NAA10 NDUFB6 NEU1 NFE2L2 NFE2L3 NFIL3 NKG7 NRG4 ORMDL1 OS9 P4HA2 PLLP PLN PLP1 PLPP1 PLTP PMP22 PNLIPRP1 PSENEN PTCH1 PTDSS1 PTPN9 RAB23 RABAC1 RHEB RIMS3 RPRM RPS3A RRAS2 RUSF1 SACM1L SAR1B SCAMP4 SCAMP5 SCLY SCP2 SEC22B SEC61G SELENOK SERINC1 SFT2D2 SFTPC SFXN3 SHMT2 SLC19A3 SLC29A1 SLC29A2 SLC29A3 SLC2A3 SLC2A4 SLC30A2 SLC35H1 SLC38A1 SLC39A13 SLC41A2 SLC41A3 SLC49A3 SLC50A1 SLC61A1 SLC7A9 SPOCK3 SQLE ST6GAL2 STARD3 STX7 STX8 SYNGR1 SYNPR TAP1 TECR TIMM17B TIMM23B TM4SF4 TMEM100 TMEM115 TMEM140 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM222 TMEM230 TMEM234 TMEM243 TMEM51 TMEM54 TRAM1 TRAM1L1 TSPAN2 TSPAN4 TSPAN7 TTLL5 UBE2J1 UNC50 USE1 VKORC1 VTI1B YIPF2 ZDHHC11 ZDHHC21 ZDHHC9
Entrez ID		50859	10488
HPRD ID		12147	07339
Ensembl ID		ENSG00000196104	ENSG00000107175
Uniprot IDs		A0A0A0MTJ2 B4DI52 Q9BQ16	O43889
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Cell Motility Extracellular Matrix Organization Regulation Of Locomotion Extracellular Structure Organization Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Locomotion Cellular Response To Genistein Positive Regulation Of Cell Motility Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Deacetylase Activity Metallopeptidase Activity Serine-type Endopeptidase Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Migration Response To Odorant Response To Genistein Regulation Of Cell-substrate Adhesion Regulation Of Leukocyte Migration GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Release From Viral Latency Astrocyte Cell Migration CCR1 Chemokine Receptor Binding Response To Phenylpropanoid Negative Regulation Of Signal Transduction Cellular Response To UV-A Extracellular Space CAMP Response Element Binding Protein Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Oxidative Stress Cellular Response To Stress Response To UV-A Chondrocyte Proliferation Positive Regulation Of Myotube Differentiation Regulation Of Cell Growth Metalloendopeptidase Inhibitor Activity Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Induction Of Positive Chemotaxis Cellular Response To Nitric Oxide Peptidase Activity Cellular Response To Reactive Nitrogen Species	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Transmembrane Transport Chemical Homeostasis Small Molecule Biosynthetic Process Endomembrane System Lipid Biosynthetic Process Homeostatic Process Uracil Transmembrane Transport Pyrimidine Nucleobase Transmembrane Transport Uracil Transmembrane Transporter Activity Lipid Metabolic Process Golgi Apparatus Golgi Membrane Structural Constituent Of Myelin Sheath Response To Endoplasmic Reticulum Stress Integrated Stress Response Signaling Cytidine Transport Guanine Transport Adenosine Transport Cytidine Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Inosine Transport Guanine Transmembrane Transport Intracellular Chemical Homeostasis Plasma Membrane Steroid Biosynthetic Process Apical Plasma Membrane Cellular Homeostasis Sterol Biosynthetic Process Lysosomal Membrane Pyrimidine-containing Compound Transmembrane Transport Small Molecule Metabolic Process Pyrimidine Nucleoside Transport Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Uridine Transmembrane Transport Water Channel Activity Nucleoside Transport Nucleoside Transmembrane Transport Pyrimidine Nucleobase Transport Membrane Organization Regulation Of Lipid Transport Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transport Chloride Channel Inhibitor Activity Protein Palmitoylation Organophosphate Biosynthetic Process