SPOCK3

Name	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
Structure	No pdb structure
Interactors	4 interactors: CREB3 MMP14 MMP3 SPOCK2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Enzyme Inhibitor Activity Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Motility
Pathways	Activation of Matrix Metalloproteinases
GWAS	Blood protein levels ( 30072576 ) Cognitive function ( 28808816 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Immune reponse to smallpox (secreted IL-10) ( 22610502 ) Medial orbital frontal cortex volume ( 31530798 ) Obesity-related traits ( 23251661 ) Total antioxidant status in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Verbal declarative memory ( 25648963 ) Weight ( 28552196 )
Entrez ID	50859
HPRD ID	12147
Ensembl ID	ENSG00000196104
Uniprot IDs	A0A0A0MTJ2 B4DI52 Q9BQ16
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Cell Motility Extracellular Matrix Organization Regulation Of Locomotion Extracellular Structure Organization Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Locomotion Cellular Response To Genistein Positive Regulation Of Cell Motility Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Deacetylase Activity Metallopeptidase Activity Serine-type Endopeptidase Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Migration Response To Odorant Response To Genistein Regulation Of Cell-substrate Adhesion Regulation Of Leukocyte Migration GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Release From Viral Latency Astrocyte Cell Migration CCR1 Chemokine Receptor Binding Response To Phenylpropanoid Negative Regulation Of Signal Transduction Cellular Response To UV-A Extracellular Space CAMP Response Element Binding Protein Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Oxidative Stress Cellular Response To Stress Response To UV-A Chondrocyte Proliferation Positive Regulation Of Myotube Differentiation Regulation Of Cell Growth Metalloendopeptidase Inhibitor Activity Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Induction Of Positive Chemotaxis Cellular Response To Nitric Oxide Peptidase Activity Cellular Response To Reactive Nitrogen Species