SPOCK3

Gene Name		sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix
	Molecular Function	Calcium Ion Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity
	Biological Process	Signal Transduction Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan
Pathways
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-10) ( 22610502) Obesity-related traits ( 23251661)
Protein-protein Interactions		3 interactors: MMP14 MMP3 SPOCK2
Entrez ID		50859
HPRD ID		12147
Ensembl ID		ENSG00000196104
Uniprot IDs		B4DI52 B4DJY3 Q9BQ16
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Oxidative Stress-induced Cell Death Astrocyte Cell Migration Response To Oxidative Stress Chondrocyte Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Cellular Response To Nitric Oxide Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Regulation Of Cell Migration Response To Nitric Oxide Regulation Of Cell Adhesion Craniofacial Suture Morphogenesis Regulation Of Cell Motility Endothelial Cell Proliferation Positive Regulation Of Protein Oligomerization Regulation Of Locomotion Negative Regulation Of Focal Adhesion Assembly Regulation Of Cellular Component Movement Cellular Response To Reactive Nitrogen Species Regulation Of Protein Oligomerization Endodermal Cell Differentiation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase B Signaling Endochondral Ossification Negative Regulation Of Reactive Oxygen Species Metabolic Process Peptide Cross-linking Regulation Of Focal Adhesion Assembly Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Cell-substrate Adhesion Endoderm Formation Chondroitin Sulfate Metabolic Process Regulation Of Cell Junction Assembly Cellular Response To Amino Acid Stimulus Glial Cell Migration Embryonic Cranial Skeleton Morphogenesis Ovarian Follicle Development Synapse Assembly Endochondral Bone Morphogenesis Endoderm Development Epithelial Cell Proliferation Proteolysis Ovulation Cycle Process
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