FUBP3 and XBP1

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		FUBP3	XBP1
Name		far upstream element binding protein 3	X-box binding protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ribosome Membrane Neuronal Cell Body Dendritic Shaft	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Protease Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular MRNA Localization Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Cell Growth Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Glandular Epithelial Cell Maturation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Response To Unfolded Protein Muscle Organ Development Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response ERAD Pathway Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of SMAD Protein Signal Transduction Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Positive Regulation Of ERAD Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
GWAS		Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Appendicular lean mass ( 33097823 ) Bone mineral density (paediatric, lower limb) ( 24945404 ) Bone mineral density (paediatric, total body less head) ( 24945404 ) Estimated glomerular filtration rate ( 31152163 ) Femoral neck bone mineral density ( 22504420 29499414 ) Fractures ( 30158200 ) Height ( 18391950 20881960 23563607 25282103 28552196 31562340 ) Serum alkaline phosphatase levels ( 33547301 )	Esophageal cancer (squamous cell) ( 22960999 ) Esophageal squamous cell carcinoma ( 25129146 ) Heel bone mineral density ( 28869591 ) Mean arterial pressure ( 29403010 ) Pancreatic cancer ( 25086665 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		14 interacting genes: APP ATXN1 CALCOCO2 CEBPA LINC00624 MARCHF8 OGT PAX9 PTEN QKI RBPMS2 RNF10 SSX1 XBP1	22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580
Entrez ID		8939	7494
HPRD ID		04640	01908
Ensembl ID		ENSG00000107164	ENSG00000100219
Uniprot IDs		Q96I24	B1AHH1 P17861
PDB IDs		Not available	6R5Q 6R6G 6R6P 6R7Q
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Developmental Maturation Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Development Learning Or Memory Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Gliogenesis Positive Regulation Of Lipid Biosynthetic Process Cognition Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myelination Regulation Of Macromolecule Biosynthetic Process Memory Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process ATF6-mediated Unfolded Protein Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II ER-nucleus Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Binding RNA Polymerase II Transcription Regulator Complex Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Regeneration Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisome Proliferator Activated Receptor Binding Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus SUMO Transferase Activity Transcription Cis-regulatory Region Binding Cellular Response To Reactive Oxygen Species Estrogen Receptor Signaling Pathway Response To Immobilization Stress Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Liver Regeneration Regeneration Sequence-specific Double-stranded DNA Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Nuclear Estrogen Receptor Binding