PMF1 and BICD2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		PMF1	BICD2
Description		polyamine modulated factor 1	BICD cargo adaptor 2
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Golgi Apparatus Cytosol	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding	Protein Binding Cytoskeletal Anchor Activity Small GTPase Binding Dynactin Binding Dynein Light Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Transcription By RNA Polymerase II Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription Cell Division	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Protein Transport Protein Localization To Golgi Apparatus MRNA Transport Centrosome Localization Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) White matter hyperintensity burden ( 25663218)	Appendicular lean mass ( 33097823) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Neutrophil count ( 32888494) Platelet count ( 32888494) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		23 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L USHBP1	51 interacting genes: ARHGAP45 CBR3 CCDC187 CCHCR1 DCTN1 DCTN2 DCX DSCR9 FAM110A FAM161A FAM161B FAM50B GSK3B HDAC4 LNX1 MFAP1 MOS NEK9 NXF1 PCM1 PMF1 POLDIP3 PPP1R18 PRC1 PRPF18 PRPF31 PRPF6 RAB6A RAB6B RBM22 RBM41 SNW1 TBRG4 TCEA2 TCEANC TFIP11 TSGA10IP USP2 UTP14A UTP14C YES1 YTHDF1 ZC2HC1C ZMAT2 ZNF417 ZNF624 ZNF648 ZNF669 ZNF670 ZSCAN12 ZSCAN23
Entrez ID		11243	23299
HPRD ID		11441	09826
Ensembl ID		ENSG00000160783	ENSG00000185963
Uniprot IDs		Q6P1K2	Q8TD16 Q96FU2
PDB IDs		5LSJ 5LSK 8PPR 8Q5H	6OFP 6PSE
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification Skeletal Muscle Satellite Cell Proliferation COP9 Signalosome COP9 Signalosome Assembly MIS12/MIND Type Complex Spindle Pole Kinetochore Skeletal Muscle Cell Proliferation Positive Regulation Of Cell Size Kinetochore Assembly Centrosome Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Kinetochore Organization Microtubule Cytoskeleton Organization Outer Kinetochore Protein Neddylation Protein-containing Complex Protein Modification By Small Protein Removal Post-translational Protein Modification Ossification CTP Binding DATP Binding Regulation Of Protein Modification Process Response To Antibiotic Protein Tyrosine Kinase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Glutathione Biosynthetic Process Mediator Complex Spindle Organization Chromosome, Centromeric Region Negative Regulation Of ARF Protein Signal Transduction Attachment Of Spindle Microtubules To Kinetochore Cell Redox Homeostasis Regulation Of Response To Wounding Regulation Of Neuroblast Proliferation Regulation Of Cell Division Muscle Cell Proliferation Protein Modification By Small Protein Conjugation	Centrosome Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Metabolic Process MRNA Metabolic Process U2-type Precatalytic Spliceosome Ciliary Basal Body Nuclear Speck Microtubule Cytoskeleton Organization Microtubule Anchoring Protein Localization To Golgi Membrane Catalytic Step 2 Spliceosome Spindle Microtubule Nucleoplasm Protein Binding Microtubule Anchoring At Centrosome Nucleus Microtubule-based Process Nucleic Acid Metabolic Process Microtubule Anchoring At Microtubule Organizing Center Microtubule Binding Cellular Response To Retinoic Acid Myosin V Binding Establishment Of Organelle Localization Zinc Ion Binding Spindle Pole Spliceosomal Tri-snRNP Complex Assembly Centriole Nucleic Acid Binding Positive Regulation Of Protein Export From Nucleus U5 SnRNP
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