PMF1 and MIS12

Number of citations of the paper that reports this interaction (PubMedID 15502821)
0

Data Source:
HPRD (in vitro, in vivo)

		PMF1	MIS12
Description		polyamine modulated factor 1	MIS12 kinetochore complex component
Image
GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Golgi Apparatus Cytosol	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding	Protein Binding
	Biological Process	Transcription By RNA Polymerase II Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription Cell Division	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) White matter hyperintensity burden ( 25663218)	Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L USHBP1	9 interacting genes: CBX3 CBX5 DSN1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		11243	79003
HPRD ID		11441	12379
Ensembl ID		ENSG00000160783	ENSG00000167842
Uniprot IDs		Q6P1K2	A8K1M4 Q9H081
PDB IDs		5LSJ 5LSK 8PPR 8Q5H	5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification Skeletal Muscle Satellite Cell Proliferation COP9 Signalosome COP9 Signalosome Assembly MIS12/MIND Type Complex Spindle Pole Kinetochore Skeletal Muscle Cell Proliferation Positive Regulation Of Cell Size Kinetochore Assembly Centrosome Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Kinetochore Organization Microtubule Cytoskeleton Organization Outer Kinetochore Protein Neddylation Protein-containing Complex Protein Modification By Small Protein Removal Post-translational Protein Modification Ossification CTP Binding DATP Binding Regulation Of Protein Modification Process Response To Antibiotic Protein Tyrosine Kinase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Glutathione Biosynthetic Process Mediator Complex Spindle Organization Chromosome, Centromeric Region Negative Regulation Of ARF Protein Signal Transduction Attachment Of Spindle Microtubules To Kinetochore Cell Redox Homeostasis Regulation Of Response To Wounding Regulation Of Neuroblast Proliferation Regulation Of Cell Division Muscle Cell Proliferation Protein Modification By Small Protein Conjugation	Outer Kinetochore Chromosome, Centromeric Region Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Skeletal Muscle Cell Proliferation Nuclear Chromosome Segregation Chromosome Cell Division Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Nuclear Body Muscle Cell Proliferation Regulation Of Meiosis I Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Nucleus Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Kinetochore Organization Positive Regulation Of Cell Cycle Checkpoint Nucleoplasm Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Pole Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Pericentric Heterochromatin Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Site Of DNA Damage Regulation Of Chromosome Organization Heterochromatin Positive Regulation Of Cell Cycle Process Regulation Of TRNA Methylation Kinetochore Adaptor Activity Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Meiotic Cell Cycle
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