PMF1 and FBXO28

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PMF1	FBXO28
Description		polyamine modulated factor 1	F-box protein 28
Image			No pdb structure
GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Golgi Apparatus Cytosol	Chromosome, Centromeric Region Kinetochore Chromosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding	Protein Binding Identical Protein Binding
	Biological Process	Transcription By RNA Polymerase II Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription Cell Division	Protein Polyubiquitination
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) White matter hyperintensity burden ( 25663218)	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		23 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L USHBP1	21 interacting genes: AGGF1 CSNK2A1 CTNNA3 EMILIN1 EMILIN3 EXOC7 GCC1 GK GOLGA2 GOLGA6L9 PFKFB4 PLEKHF2 PMF1 PSMC3 SDCBP2 SNAI2 SPAG5 STX1B TOP2A TRAF2 VHL
Entrez ID		11243	23219
HPRD ID		11441	12367
Ensembl ID		ENSG00000160783	ENSG00000143756
Uniprot IDs		Q6P1K2	Q9NVF7
PDB IDs		5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification Skeletal Muscle Satellite Cell Proliferation COP9 Signalosome COP9 Signalosome Assembly MIS12/MIND Type Complex Spindle Pole Kinetochore Skeletal Muscle Cell Proliferation Positive Regulation Of Cell Size Kinetochore Assembly Centrosome Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Kinetochore Organization Microtubule Cytoskeleton Organization Outer Kinetochore Protein Neddylation Protein-containing Complex Protein Modification By Small Protein Removal Post-translational Protein Modification Ossification CTP Binding DATP Binding Regulation Of Protein Modification Process Response To Antibiotic Protein Tyrosine Kinase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Glutathione Biosynthetic Process Mediator Complex Spindle Organization Chromosome, Centromeric Region Negative Regulation Of ARF Protein Signal Transduction Attachment Of Spindle Microtubules To Kinetochore Cell Redox Homeostasis Regulation Of Response To Wounding Regulation Of Neuroblast Proliferation Regulation Of Cell Division Muscle Cell Proliferation Protein Modification By Small Protein Conjugation
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