PAX3 and DAXX

Number of citations of the paper that reports this interaction (PMID 10393185)
60

Data Source:
HPRD (in vivo)

		PAX3	DAXX
Gene Name		paired box 3	death-domain associated protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Chromosome, Centromeric Region Heterochromatin Nucleus Nucleolus Cytoplasm Cytosol PML Body SWI/SNF Superfamily-type Complex
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding	P53 Binding Transcription Corepressor Activity Receptor Signaling Protein Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Neural Tube Closure Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Sensory Perception Of Sound Cell Proliferation Positive Regulation Of Cell Proliferation Organ Morphogenesis Regulation Of Somitogenesis Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Pigmentation Neuron Fate Commitment Mammary Gland Specification	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Facial morphology ( 22341974)
Protein-Protein Interactions		15 interactors: CIB1 DAXX HDAC10 IPO13 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1	82 interactors: AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP DAPK3 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3F3A HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HIST1H3C HIST1H4F HIST4H4 HSF1 HSPB1 MAP3K5 MCRS1 MDM2 MST1 MX1 MYH11 NECAB2 NR3C1 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PRMT1 RASSF1 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STUB1 SUMO1 TCF3 TCF7L2 TGFB1 TGFB2 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBE2I USP7 WHSC1L1
Entrez ID		5077	1616
HPRD ID		09421	04424
Ensembl ID		ENSG00000135903	ENSG00000204209
Uniprot IDs		P23760	B4E1C1 F5ANJ6 F5ANJ7 Q53F85 Q9UER7
PDB IDs		3CMY	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Mesenchyme Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stem Cell Differentiation Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Mesenchymal Cell Differentiation Epithelium Development Tissue Development Glial Cell Differentiation Somite Specification Gliogenesis Regulation Of Cell Proliferation Oligodendrocyte Differentiation Organ Development Regulation Of Cell Differentiation Enteric Nervous System Development System Development Peripheral Nervous System Development Mesenchymal Cell Development	Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cell Death Regulation Of Signal Transduction Death Apoptotic Process Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Signaling Transcription, DNA-templated Cellular Response To Stress Cellular Aromatic Compound Metabolic Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Response To Stimulus Chromosome Organization Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
Tagcloud ?		6ped activators alveolar arms chimeric chromosomal copies cotransfected diphtheria effort exploit fkhr harbor lacks p36 pa3 pax7 plasmid plasmids prs q14 q35 rearrangements rhabdomyosarcoma sorting stably toxin transfections translocations	adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?		6ped activators alveolar arms chimeric chromosomal copies cotransfected diphtheria effort exploit fkhr harbor lacks p36 pa3 pax7 plasmid plasmids prs q14 q35 rearrangements rhabdomyosarcoma sorting stably toxin transfections translocations	adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?