PAX3 and HDAC10

Number of citations of the paper that reports this interaction (PMID 20032463)
9

Data Source:
BioGRID (pull down, pull down)

		PAX3	HDAC10
Gene Name		paired box 3	histone deacetylase 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding	Histone Deacetylase Activity Protein Binding Enzyme Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Neural Tube Closure Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Sensory Perception Of Sound Cell Proliferation Positive Regulation Of Cell Proliferation Organ Morphogenesis Regulation Of Somitogenesis Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Pigmentation Neuron Fate Commitment Mammary Gland Specification	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Deacetylation Notch Signaling Pathway Oligodendrocyte Development Chromatin Modification Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Facial morphology ( 22341974)
Protein-Protein Interactions		15 interactors: CIB1 DAXX HDAC10 IPO13 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1	7 interactors: HDAC2 HDAC3 HSPA8 MDC1 NCOR2 PAX3 TRIM28
Entrez ID		5077	83933
HPRD ID		09421	09407
Ensembl ID		ENSG00000135903	ENSG00000100429
Uniprot IDs		P23760	C9J8B8 Q969S8
PDB IDs		3CMY
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Mesenchyme Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stem Cell Differentiation Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Mesenchymal Cell Differentiation Epithelium Development Tissue Development Glial Cell Differentiation Somite Specification Gliogenesis Regulation Of Cell Proliferation Oligodendrocyte Differentiation Organ Development Regulation Of Cell Differentiation Enteric Nervous System Development System Development Peripheral Nervous System Development Mesenchymal Cell Development	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone H4 Deacetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Histone H3 Deacetylation Nitrogen Compound Metabolic Process RNA Metabolic Process Histone H3-K9 Modification Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Gene Expression Rhythmic Process Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Deacetylation Cellular Response To Heat Epithelium Development Protein Deacetylation Embryo Development Anatomical Structure Morphogenesis Circadian Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibril Organization Heart Development Positive Regulation Of Protein Import Into Nucleus Biosynthetic Process Response To Heat Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus
Tagcloud ?		6ped activators alveolar arms chimeric chromosomal copies cotransfected diphtheria effort exploit fkhr harbor lacks p36 pa3 pax7 plasmid plasmids prs q14 q35 rearrangements rhabdomyosarcoma sorting stably toxin transfections translocations	acetylated acetyltransferase alphav attachment cerebroside deacetylases dysregulation ebpalpha finger greatly hcc hdac9 hepatocellular implanted integrin intrahepatic intriguingly lost metastasis mir monocytic moz myst orthotopic orthotopically smmc sulfatide sulfotransferase verified
Tagcloud (Difference) ?		6ped activators alveolar arms chimeric chromosomal copies cotransfected diphtheria effort exploit fkhr harbor lacks p36 pa3 pax7 plasmid plasmids prs q14 q35 rearrangements rhabdomyosarcoma sorting stably toxin transfections translocations	acetylated acetyltransferase alphav attachment cerebroside deacetylases dysregulation ebpalpha finger greatly hcc hdac9 hepatocellular implanted integrin intrahepatic intriguingly lost metastasis mir monocytic moz myst orthotopic orthotopically smmc sulfatide sulfotransferase verified
Tagcloud (Intersection) ?