CDC42EP1 and PLSCR1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		CDC42EP1	PLSCR1
Description		CDC42 effector protein 1	phospholipid scramblase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Endomembrane System Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Involved In Cell-cell Adhesion	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Hydrolase Activity SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Cell-cell Adhesion	Phosphatidylserine Biosynthetic Process Lipid Transport Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS			Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		13 interacting genes: ARMC7 CDC42 DEF6 FHL3 KRTAP4-12 MAPKAP1 MDFI OGT PLSCR1 PRKAA2 RBPMS RHOQ SAT1	132 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MDK MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PPDPF PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG THBS1 TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764
Entrez ID		11135	5359
HPRD ID		07303	08855
Ensembl ID		ENSG00000128283	ENSG00000188313
Uniprot IDs		Q00587	C9J7K9 O15162
PDB IDs			1Y2A
Enriched GO Terms of Interacting Partners?		GBD Domain Binding TOR Signaling Organelle Organization Protein Kinase Binding Cytosol Filopodium Endothelin Receptor Signaling Pathway Involved In Heart Process Substantia Nigra Development Regulation Of Filopodium Assembly Neural Nucleus Development Positive Regulation Of Filopodium Assembly Intracellular Signal Transduction Storage Vacuole Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Protein Localization To Lysosome Cellular Response To Glucose Stimulus Positive Regulation Of TOR Signaling Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Negative Regulation Of Translational Initiation [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Intracellular Glucose Homeostasis Positive Regulation Of Translational Initiation Regulation Of Purine Nucleotide Metabolic Process Cellular Response To Nutrient Levels TORC1 Signaling Response To Hormone Cellular Response To Hormone Stimulus Diamine N-acetyltransferase Activity Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Small GTPase Mediated Signal Transduction Phosphatidylinositol-3,4,5-trisphosphate Binding Response To Peptide Hormone Response To Insulin Regulation Of Insulin Receptor Signaling Pathway Protein O-acetylglucosaminyltransferase Activity Insulin Receptor Signaling Pathway Establishment Of Cell Polarity	Enzyme Binding Ephrin Receptor Binding Protein Binding Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Keratin Filament Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Intermediate Filament Response To Growth Factor Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Helper T Cell Diapedesis Shc-EGFR Complex Positive Regulation Of Cell-substrate Adhesion Regulation Of Superoxide Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Response To Lipid Hair Cycle Apoptotic Process Regulation Of Focal Adhesion Assembly Regulation Of MAPK Cascade Cerebellar Neuron Development Regulation Of Apoptotic Process Protein Tyrosine Kinase Activator Activity Cellular Response To Lipid Morphogenesis Of A Branching Structure ERBB Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Cell-substrate Junction Organization Gland Development Regulation Of RNA Biosynthetic Process Programmed Cell Death Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding System Development Regulation Of Cell Population Proliferation Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Regulation Of Cell-matrix Adhesion Positive Regulation Of Superoxide Anion Generation Central Nervous System Neuron Development
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