FURIN and NOTCH1

Number of citations of the paper that reports this interaction (PMID 9653148)
126

Data Source:
HPRD (in vitro)

		FURIN	NOTCH1
Gene Name		furin (paired basic amino acid cleaving enzyme)	notch 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Trans-Golgi Network Transport Vesicle Membrane Raft Extracellular Vesicular Exosome	Golgi Membrane Acrosomal Vesicle MAML1-RBP-Jkappa- ICN1 Complex Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding	Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Enzyme Inhibitor Activity Receptor Activity Calcium Ion Binding Protein Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Pathogenesis Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Viral Process Protein Processing Peptide Hormone Processing Peptidyl-glutamic Acid Carboxylation Viral Life Cycle Virion Assembly Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Nerve Growth Factor Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Specification Epithelial To Mesenchymal Transition Liver Development Heart Looping Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Inflammatory Response To Antigenic Stimulus Endocardium Development Endocardium Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Mitral Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Chamber Formation Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Formation Ventricular Trabecula Myocardium Morphogenesis Growth Involved In Heart Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cell Migration Involved In Endocardial Cushion Formation Pericardium Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Immune Response Humoral Immune Response Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Spermatogenesis Determination Of Left/right Symmetry Compartment Pattern Specification Axonogenesis Foregut Morphogenesis Endoderm Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Auditory Receptor Cell Fate Commitment Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myotube Differentiation Mesenchymal Cell Development Regulation Of Somitogenesis Cell Differentiation In Spinal Cord Neural Tube Development Keratinocyte Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Hair Follicle Morphogenesis Organ Regeneration Response To Corticosteroid Response To Muramyl Dipeptide Response To Lipopolysaccharide Embryonic Hindlimb Morphogenesis Tube Formation Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Tissue Regeneration Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of JAK-STAT Cascade Negative Regulation Of Photoreceptor Cell Differentiation Somatic Stem Cell Division Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Glial Cell Proliferation Cilium Morphogenesis Cardiac Epithelial To Mesenchymal Transition Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Prostate Gland Epithelium Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Arterial Endothelial Cell Differentiation Venous Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Endocardial Cell Differentiation Vasculogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Notch Signaling Involved In Heart Development Heart Trabecula Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Cellular Response To Follicle-stimulating Hormone Stimulus Distal Tubule Development Collecting Duct Development Glomerular Mesangial Cell Development Interleukin-4 Secretion Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Extracellular Matrix Assembly Apoptotic Process Involved In Embryonic Digit Morphogenesis Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Anoikis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Chemotaxis
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Degradation of the extracellular matrix Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Assembly Of The HIV Virion HIV Life Cycle Uptake and actions of bacterial toxins NGF processing Removal of aminoterminal propeptides from gamma-carboxylated proteins Pre-NOTCH Expression and Processing Uptake and function of anthrax toxins Signaling by NODAL Signaling by PDGF Signalling by NGF TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Pre-NOTCH Processing in Golgi Loss of Function of SMAD2/3 in Cancer Post-translational protein modification Collagen degradation Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Activation of Matrix Metalloproteinases Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Synthesis and processing of ENV and VPU Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Gamma carboxylation, hypusine formation and arylsulfatase activation SMAD4 MH2 Domain Mutants in Cancer	Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Pre-NOTCH Processing in the Endoplasmic Reticulum Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Regulation of beta-cell development Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Pre-NOTCH Processing in Golgi Signaling by NOTCH Notch-HLH transcription pathway Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS		Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		27 interactors: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 COL23A1 DSG3 EDA FLNA FLNC ITM2C LECT1 LRP1 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	56 interactors: ADAM17 AKT1 APBA1 BLOC1S1 CACNA1A CAMK4 CBL CNTN1 CTNNB1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 FBXW7 FURIN GFI1B GSK3B ILK ITCH JAG1 JAG2 KAT2A KAT2B LCK LEF1 LFNG MAML1 MAML2 MAML3 MDM2 MEF2C MFNG NFKB1 NOV NUMB NUMBL PIK3CG POFUT1 PSEN1 PSEN2 RBP3 RBPJ REL RELA RUNX3 SMAD3 SNAI1 SNW1 USP12 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID		5045	4851
HPRD ID		00653	01827
Ensembl ID		ENSG00000140564	ENSG00000148400
Uniprot IDs		P09958	P46531
PDB IDs			1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Acrosome Reaction Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Multicellular Organismal Development Developmental Process Anatomical Structure Development Regulation Of Acrosome Reaction Platelet Degranulation Protein Targeting To Lysosome Regulation Of Cellular Localization Protein Localization To Lysosome Vesicle-mediated Transport Positive Regulation Of Transport Establishment Of Protein Localization Cellular Localization Hair Follicle Development Positive Regulation Of Humoral Immune Response Hair Cycle Process Positive Regulation Of Calcium Ion-dependent Exocytosis System Development Membrane Protein Ectodomain Proteolysis Secretion By Cell Protein Targeting To Golgi Hair Cycle Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Protein Targeting To Vacuole Regulation Of Defense Response To Virus By Virus Establishment Of Protein Localization To Vacuole Regulation Of Immune System Process Regulation Of Cell Migration Heart Trabecula Morphogenesis Protein Kinase C Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Exocytosis Regulation Of Cell Motility Secretion Protein Transport Regulation Of Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Membrane Protein Proteolysis Regulation Of Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport Protein Localization To Golgi Apparatus Protein Localization Regulation Of Locomotion	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction System Development Cellular Response To Stimulus Positive Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Regulation Of Signal Transduction Anatomical Structure Development Epithelium Development Regulation Of Signaling Positive Regulation Of Signal Transduction Developmental Process Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Nervous System Development Regulation Of Cell Differentiation Regulation Of Cell Development Positive Regulation Of Transcription, DNA-templated Pattern Specification Process Cell Differentiation Regulation Of Cell Death Tissue Development Generation Of Neurons Morphogenesis Of An Epithelium Regulation Of Gene Expression Notch Receptor Processing Negative Regulation Of Cell Death Positive Regulation Of Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Organ Morphogenesis Regulation Of Metabolic Process Neurogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Somitogenesis Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Apoptotic Process
Tagcloud ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	a23187 alpha1 antitrypsin biologically carboxyl cleaved convertase convertases decisions dibasic digestion disagree exists extend fate furin heterodimeric invertebrates ionophore lovo nearby pdx processed processing proteolytic rqrr takes vertebrates
Tagcloud (Difference) ?		autophosphorylation c5 cleavage cleave d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda participate posttranslational proprotein restore totally trypsin unable unprocessed unresponsive	a23187 alpha1 antitrypsin biologically carboxyl convertase decisions dibasic digestion disagree exists extend fate heterodimeric invertebrates ionophore nearby pdx processing proteolytic rqrr takes vertebrates
Tagcloud (Intersection) ?		cleaved convertases furin lovo processed