FURIN and ADAMTS4

Number of citations of the paper that reports this interaction (PubMedID 14744861)
0

Data Source:
HPRD (in vivo)

		FURIN	ADAMTS4
Description		furin, paired basic amino acid cleaving enzyme	ADAM metallopeptidase with thrombospondin type 1 motif 4
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endosome Endoplasmic Reticulum Golgi Apparatus Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Organelle Membrane Membrane Raft Extracellular Exosome Golgi Apparatus Subcompartment	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding Endopeptidase Activator Activity Heparan Sulfate Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Blastocyst Formation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Protein Processing Peptide Hormone Processing Viral Life Cycle Viral Translation Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Zymogen Activation Regulation Of Cholesterol Transport Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Plasma Lipoprotein Particle Remodeling Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Positive Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Dibasic Protein Processing Zymogen Inhibition Cytokine Precursor Processing Amyloid Fibril Formation	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium
Pathways		Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Potential therapeutics for SARS Attachment and Entry Induction of Cell-Cell Fusion Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry Maturation of hRSV A proteins	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		Capric acid
Diseases
GWAS		Age at first sexual intercourse ( 34211149 27089180) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 34002096) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Hypertension ( 21909115 30487518) Language functional connectivity ( 34929384) Left-handedness ( 32989287) Mean arterial pressure ( 27618448 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 30285260 25056061) Systolic blood pressure ( 28739976 28135244 27618452 29403010 26390057 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 32888494)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 27182965 31361310 31619474) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 27863252 32888494)
Interacting Genes		29 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 CNMD COL23A1 DSG3 EDA FLNA FLNC ITM2C LRP1 MMP14 NAGPA NAPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		5045	9507
HPRD ID		00653	04853
Ensembl ID		ENSG00000140564	ENSG00000158859
Uniprot IDs		P09958	O75173
PDB IDs		4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 6YD2 6YD3 6YD4 6YD7 7LCU 7O1U 7O1W 7O1Y 7O20 7O22 7QXY 7QXZ 7QY0 7QY1 7QY2 8B4V 8B4W 8B4X 8OYH	2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?		Extracellular Region Regulation Of Cell Motility Regulation Of Locomotion Extracellular Matrix Regulation Of Cell Migration Amyloid Precursor Protein Catabolic Process Extracellular Space Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Humoral Immune Response Regulation Of Smooth Muscle Cell Migration Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Structural Constituent Of Egg Coat Egg Coat Positive Regulation Of Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Locomotion Amyloid-beta Binding Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Gene Expression Metalloendopeptidase Activity Cellular Developmental Process Regulation Of Glial Cell Proliferation Positive Regulation Of Acrosome Reaction Regulation Of Cellular Localization Regulation Of Humoral Immune Response Lysosomal Transport Plasma Membrane Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Cell Activation Negative Regulation Of Neurogenesis Metallopeptidase Activity Amyloid-beta Formation Transmembrane Transporter Binding Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Nervous System Development Integrin Binding Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Mononuclear Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Developmental Process Regulation Of Acrosome Reaction Gene Expression	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing
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