FURIN and DSG3

Number of citations of the paper that reports this interaction (PMID 12586364)
8

Data Source:
HPRD (in vitro, in vivo)

		FURIN	DSG3
Gene Name		furin (paired basic amino acid cleaving enzyme)	desmoglein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Trans-Golgi Network Transport Vesicle Membrane Raft Extracellular Vesicular Exosome	Cytosol Plasma Membrane Integral Component Of Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding	Calcium Ion Binding
	Biological Process	Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Pathogenesis Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Viral Process Protein Processing Peptide Hormone Processing Peptidyl-glutamic Acid Carboxylation Viral Life Cycle Virion Assembly Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Nerve Growth Factor Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Degradation of the extracellular matrix Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Assembly Of The HIV Virion HIV Life Cycle Uptake and actions of bacterial toxins NGF processing Removal of aminoterminal propeptides from gamma-carboxylated proteins Pre-NOTCH Expression and Processing Uptake and function of anthrax toxins Signaling by NODAL Signaling by PDGF Signalling by NGF TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Pre-NOTCH Processing in Golgi Loss of Function of SMAD2/3 in Cancer Post-translational protein modification Collagen degradation Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Activation of Matrix Metalloproteinases Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Synthesis and processing of ENV and VPU Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Gamma carboxylation, hypusine formation and arylsulfatase activation SMAD4 MH2 Domain Mutants in Cancer	Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)	Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		27 interactors: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 COL23A1 DSG3 EDA FLNA FLNC ITM2C LECT1 LRP1 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	4 interactors: CASP3 FURIN JUP PKP3
Entrez ID		5045	1830
HPRD ID		00653	01355
Ensembl ID		ENSG00000140564	ENSG00000134757
Uniprot IDs		P09958	P32926
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Acrosome Reaction Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Multicellular Organismal Development Developmental Process Anatomical Structure Development Regulation Of Acrosome Reaction Platelet Degranulation Protein Targeting To Lysosome Regulation Of Cellular Localization Protein Localization To Lysosome Vesicle-mediated Transport Positive Regulation Of Transport Establishment Of Protein Localization Cellular Localization Hair Follicle Development Positive Regulation Of Humoral Immune Response Hair Cycle Process Positive Regulation Of Calcium Ion-dependent Exocytosis System Development Membrane Protein Ectodomain Proteolysis Secretion By Cell Protein Targeting To Golgi Hair Cycle Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Protein Targeting To Vacuole Regulation Of Defense Response To Virus By Virus Establishment Of Protein Localization To Vacuole Regulation Of Immune System Process Regulation Of Cell Migration Heart Trabecula Morphogenesis Protein Kinase C Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Exocytosis Regulation Of Cell Motility Secretion Protein Transport Regulation Of Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Membrane Protein Proteolysis Regulation Of Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport Protein Localization To Golgi Apparatus Protein Localization Regulation Of Locomotion	Desmosome Assembly Desmosome Organization Establishment Of Protein Localization To Plasma Membrane Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Matrix Disassembly Cell-cell Junction Assembly Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Localization To Plasma Membrane Nerve Growth Factor Production Cell Junction Assembly Cell-cell Junction Organization Endothelial Cell-cell Adhesion Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Skin Development Plasma Membrane Organization Neurotrophin Signaling Pathway Establishment Of Protein Localization To Membrane Protein Processing Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Indole-3-methanol Positive Regulation Of Proteolysis Negative Regulation Of Transforming Growth Factor Beta Production Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Bundle Of His Cell To Purkinje Myocyte Communication Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Viral Protein Processing Cytoskeletal Anchoring At Plasma Membrane Cellular Response To Organic Substance Endomembrane System Organization Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Negative Regulation Of B Cell Proliferation Single Organismal Cell-cell Adhesion Signal Peptide Processing Apoptotic DNA Fragmentation Regulation Of Cell Fate Specification Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Growth Factor Stimulus Platelet Formation
Tagcloud ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg2 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg2 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Intersection) ?