FURIN and ZP3

Number of citations of the paper that reports this interaction (PMID 11804956)
4

Data Source:
HPRD (in vitro)

		FURIN	ZP3
Gene Name		furin (paired basic amino acid cleaving enzyme)	zona pellucida glycoprotein 3 (sperm receptor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Trans-Golgi Network Transport Vesicle Membrane Raft Extracellular Vesicular Exosome	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding
	Biological Process	Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Pathogenesis Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Viral Process Protein Processing Peptide Hormone Processing Peptidyl-glutamic Acid Carboxylation Viral Life Cycle Virion Assembly Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Nerve Growth Factor Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Degradation of the extracellular matrix Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Assembly Of The HIV Virion HIV Life Cycle Uptake and actions of bacterial toxins NGF processing Removal of aminoterminal propeptides from gamma-carboxylated proteins Pre-NOTCH Expression and Processing Uptake and function of anthrax toxins Signaling by NODAL Signaling by PDGF Signalling by NGF TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Pre-NOTCH Processing in Golgi Loss of Function of SMAD2/3 in Cancer Post-translational protein modification Collagen degradation Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Activation of Matrix Metalloproteinases Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Synthesis and processing of ENV and VPU Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Gamma carboxylation, hypusine formation and arylsulfatase activation SMAD4 MH2 Domain Mutants in Cancer	Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS		Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		27 interactors: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 COL23A1 DSG3 EDA FLNA FLNC ITM2C LECT1 LRP1 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		5045	7784
HPRD ID		00653	01690
Ensembl ID		ENSG00000140564	ENSG00000188372
Uniprot IDs		P09958	P21754
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Acrosome Reaction Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Multicellular Organismal Development Developmental Process Anatomical Structure Development Regulation Of Acrosome Reaction Platelet Degranulation Protein Targeting To Lysosome Regulation Of Cellular Localization Protein Localization To Lysosome Vesicle-mediated Transport Positive Regulation Of Transport Establishment Of Protein Localization Cellular Localization Hair Follicle Development Positive Regulation Of Humoral Immune Response Hair Cycle Process Positive Regulation Of Calcium Ion-dependent Exocytosis System Development Membrane Protein Ectodomain Proteolysis Secretion By Cell Protein Targeting To Golgi Hair Cycle Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Protein Targeting To Vacuole Regulation Of Defense Response To Virus By Virus Establishment Of Protein Localization To Vacuole Regulation Of Immune System Process Regulation Of Cell Migration Heart Trabecula Morphogenesis Protein Kinase C Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Exocytosis Regulation Of Cell Motility Secretion Protein Transport Regulation Of Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Membrane Protein Proteolysis Regulation Of Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport Protein Localization To Golgi Apparatus Protein Localization Regulation Of Locomotion	Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction
Tagcloud ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Difference) ?		autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Intersection) ?