KRT34 and SMARCE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT34	SMARCE1
Description		keratin 34	SWI/SNF related BAF chromatin remodeling complex subunit E1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Neurogenesis Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Keratinization Formation of the cornified envelope	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 30929738 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		261 interacting genes: A1CF ABHD15 ABI2 ADRA2C AGXT AIMP2 ALDH3B1 AMOT ANKRD11 ANKS1A ARMC7 ASMTL ATG9A ATOSB ATPAF2 BATF2 BCAS2 BEX1 BEX2 BEX3 BHLHE23 BOLA3 BRME1 C11orf87 C17orf50 C1orf216 CBX8 CCDC120 CCDC13 CCDC146 CCDC196 CCDC198 CCDC24 CCDC28A-AS1 CCHCR1 CCNC CDC20B CDK18 CERK CFAP206 CFAP53 CFAP90 CHRD CHRNG CLCNKA CLDN19 CLEC18A CTRC CWC25 CYSRT1 CYTH4 DCTN3 DDIT4L DDX6 DHRS1 DMRT3 DOCK2 EFCAB3 EIF4G1 EPDR1 EXOC8 EXOSC5 FAM110A FAM50B FAM83A FAM90A1 FARS2 FBXL9P FBXW5 FNDC11 FOXD4L1 FRS3 GADD45GIP1 GARIN6 GAST GATAD2A GEM GLYCTK GNE GNG10 GNG13 GPS2 GRN GSC2 GSTP1 HAPLN2 HBA1 HBA2 HCK HDAC4 HGS HOXA1 HOXB5 HOXB9 HOXC8 HSPA12B HSPD1 HYAL2 ICAM4 INIP INO80B ISCU ITGB5 ITPKB JOSD1 KANK2 KCTD9 KDELR1 KIDINS220 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT77 KRT78 KRT79 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP26-1 LMO2 LMO4 LRRC41 LYSMD1 LYVE1 MAB21L2 MAD2L2 MAP3K7CL MAPKBP1 MATR3 MBD3L2 METTL17 MIDN MIIP MKRN3 MNS1 MOS MSRB3 MYO15B MYOZ1 MYOZ3 NAB2 NAXD NEK6 NFKBID NMU NOTO NPBWR2 NUP42 P2RX7 PDE9A PDGFRB PGAP6 PGLYRP3 PIN1 PITX1 PITX2 PKN1 PLLP POP5 PPP1R18 PPP1R27 PPP3R2 PRF1 PRPF18 PRPF31 PRR19 PRR35 PSMA1 PSMB1 PTPMT1 R3HDM2 RAB33A RAB3IL1 RASD1 RFC5 RIN1 RIPPLY1 RPS19BP1 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SIRPA SLC15A2 SLC22A5 SLC23A1 SLC25A42 SMARCD1 SMARCE1 SMCP SMG9 SNRPB SPAG8 SPATA46 SPRY3 STMN3 SUOX TACO1 TAPBPL TBC1D22B TCHP TEKT3 TEKT4 TENT5B TEPSIN TFAP2D THAP7 TLE5 TLX3 TMEM174 TMIE TMSB4X TRARG1 TRIM42 TRIM73 TRIML2 TSG101 TTC23 TTC9C TXLNA TXLNB USP2 UTP14C UTP23 VENTX WDR25 WWOX ZDHHC1 ZFHX3 ZFYVE26 ZIC1 ZNF124 ZNF148 ZNF319 ZNF414 ZNF446 ZNF580 ZNF581 ZNF79	94 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEBPA CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ERG ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 HUNK IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OGT OIP5 PGR PSMC6 RALBP1 RARB RCOR1 RELB RINT1 RSPH1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TIAM1 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52
Entrez ID		3885	6605
HPRD ID		04137	04382
Ensembl ID		ENSG00000131737	ENSG00000073584
Uniprot IDs		O76011	Q969G3
PDB IDs			6LTH 6LTJ 7CYU 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Keratinization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Supramolecular Fiber Organization Cytoskeleton Organization Axonemal A Tubule Inner Sheath Polymeric Cytoskeletal Fiber Axonemal Microtubule	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Receptor-mediated Signaling Pathway Morphogenesis Of An Epithelium Cytoskeleton Tissue Morphogenesis Estrogen Response Element Binding Chromatin Structural Molecule Activity Protein Binding Intracellular Receptor Signaling Pathway Cytoskeleton Organization Organelle Organization Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Steroid Binding Nuclear Receptor Activity Supramolecular Fiber Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Epithelial Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Sin3-type Complex Estrogen Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Cytosol Positive Regulation Of RNA Metabolic Process Epidermis Development Cell Differentiation DNA-binding Transcription Factor Activity Protein-containing Complex Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Developmental Process Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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