KRT34 and HYAL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT34	HYAL2
Description		keratin 34	hyaluronidase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament	Golgi Membrane Cytoplasm Lysosome Endoplasmic Reticulum Cytosol Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex Side Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Virus Receptor Activity Transcription Coactivator Activity Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Enzyme Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Hyaluronoglucuronidase Activity Transforming Growth Factor Beta Binding
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization	Response To Reactive Oxygen Species Kidney Development Hematopoietic Progenitor Cell Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Response To Virus Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Urine Volume Monocyte Activation Positive Regulation Of Protein Import Into Nucleus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Symbiont Entry Into Host Cell Skeletal System Morphogenesis Positive Regulation Of Inflammatory Response Cartilage Development Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Renal Water Absorption Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Keratinization Formation of the cornified envelope	Hyaluronan metabolism Hyaluronan degradation
Drugs
Diseases
GWAS			Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		261 interacting genes: A1CF ABHD15 ABI2 ADRA2C AGXT AIMP2 ALDH3B1 AMOT ANKRD11 ANKS1A ARMC7 ASMTL ATG9A ATOSB ATPAF2 BATF2 BCAS2 BEX1 BEX2 BEX3 BHLHE23 BOLA3 BRME1 C11orf87 C17orf50 C1orf216 CBX8 CCDC120 CCDC13 CCDC146 CCDC196 CCDC198 CCDC24 CCDC28A-AS1 CCHCR1 CCNC CDC20B CDK18 CERK CFAP206 CFAP53 CFAP90 CHRD CHRNG CLCNKA CLDN19 CLEC18A CTRC CWC25 CYSRT1 CYTH4 DCTN3 DDIT4L DDX6 DHRS1 DMRT3 DOCK2 EFCAB3 EIF4G1 EPDR1 EXOC8 EXOSC5 FAM110A FAM50B FAM83A FAM90A1 FARS2 FBXL9P FBXW5 FNDC11 FOXD4L1 FRS3 GADD45GIP1 GARIN6 GAST GATAD2A GEM GLYCTK GNE GNG10 GNG13 GPS2 GRN GSC2 GSTP1 HAPLN2 HBA1 HBA2 HCK HDAC4 HGS HOXA1 HOXB5 HOXB9 HOXC8 HSPA12B HSPD1 HYAL2 ICAM4 INIP INO80B ISCU ITGB5 ITPKB JOSD1 KANK2 KCTD9 KDELR1 KIDINS220 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT77 KRT78 KRT79 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP26-1 LMO2 LMO4 LRRC41 LYSMD1 LYVE1 MAB21L2 MAD2L2 MAP3K7CL MAPKBP1 MATR3 MBD3L2 METTL17 MIDN MIIP MKRN3 MNS1 MOS MSRB3 MYO15B MYOZ1 MYOZ3 NAB2 NAXD NEK6 NFKBID NMU NOTO NPBWR2 NUP42 P2RX7 PDE9A PDGFRB PGAP6 PGLYRP3 PIN1 PITX1 PITX2 PKN1 PLLP POP5 PPP1R18 PPP1R27 PPP3R2 PRF1 PRPF18 PRPF31 PRR19 PRR35 PSMA1 PSMB1 PTPMT1 R3HDM2 RAB33A RAB3IL1 RASD1 RFC5 RIN1 RIPPLY1 RPS19BP1 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SIRPA SLC15A2 SLC22A5 SLC23A1 SLC25A42 SMARCD1 SMARCE1 SMCP SMG9 SNRPB SPAG8 SPATA46 SPRY3 STMN3 SUOX TACO1 TAPBPL TBC1D22B TCHP TEKT3 TEKT4 TENT5B TEPSIN TFAP2D THAP7 TLE5 TLX3 TMEM174 TMIE TMSB4X TRARG1 TRIM42 TRIM73 TRIML2 TSG101 TTC23 TTC9C TXLNA TXLNB USP2 UTP14C UTP23 VENTX WDR25 WWOX ZDHHC1 ZFHX3 ZFYVE26 ZIC1 ZNF124 ZNF148 ZNF319 ZNF414 ZNF446 ZNF580 ZNF581 ZNF79	16 interacting genes: CYSRT1 FHL3 KRT31 KRT34 KRTAP1-1 KRTAP10-3 KRTAP3-2 KRTAP6-2 KRTAP6-3 MST1R PELI2 SMAD2 SMAD3 SMAD4 TRIM54 WWOX
Entrez ID		3885	8692
HPRD ID		04137	04649
Ensembl ID		ENSG00000131737	ENSG00000068001
Uniprot IDs		O76011	Q12891
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Keratinization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Supramolecular Fiber Organization Cytoskeleton Organization Axonemal A Tubule Inner Sheath Polymeric Cytoskeletal Fiber Axonemal Microtubule	Intermediate Filament Keratin Filament SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Response To Transforming Growth Factor Beta SMAD Protein Signal Transduction R-SMAD Binding Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Activin Receptor Signaling Pathway Endoderm Development Mesoderm Morphogenesis Gastrulation Pericardium Development Trophoblast Cell Migration Epithelial Cell Differentiation Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Transforming Growth Factor Beta Stimulus Tissue Morphogenesis Tissue Development Embryonic Foregut Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal System Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Extrinsic Apoptotic Signaling Pathway Response To Growth Factor Regulation Of Extracellular Matrix Assembly Response To Glucose Morphogenesis Of An Epithelium Ameboidal-type Cell Migration Osteoblast Differentiation Adrenal Gland Development Response To Monosaccharide Positive Regulation Of Extracellular Matrix Organization Epidermis Development Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytosol Response To Carbohydrate
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?