ORM2 and STK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ORM2	STK3
Gene Name		orosomucoid 2	serine/threonine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Cytosol
	Molecular Function		Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Regulation Of Immune System Process Transport Acute-phase Response	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CYP39A1 PRDX6 STK3	33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		5005	6788
HPRD ID		00725	05433
Ensembl ID		ENSG00000228278	ENSG00000104375
Uniprot IDs		P19652	B3KYA7 Q13188
PDB IDs		3APU 3APV 3APW 3APX	4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Response To Reactive Oxygen Species Lipid Catabolic Process Bile Acid Catabolic Process Response To Oxidative Stress Primitive Hemopoiesis Cholesterol Catabolic Process Regulation Of Axon Regeneration Hydrogen Peroxide Catabolic Process Endocardium Development Hepatocyte Apoptotic Process Bile Acid Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Steroid Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Phospholipid Catabolic Process Hippo Signaling Embryonic Hemopoiesis Hydrogen Peroxide Metabolic Process Cell Differentiation Involved In Embryonic Placenta Development Bile Acid Metabolic Process Negative Regulation Of Organ Growth	Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?		9q31 a1l4r1 af495724 ambp belgian boundaries c9orf91 ensestg000000230601 flanking french genotyped intronic kif12 linkage lying orm1 portuguese positional refine replicate resequence resequenced rs3181357 spa spa2 spondylarthritis tnfsf15 tnfsf8 znf618	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?		9q31 a1l4r1 af495724 ambp belgian boundaries c9orf91 ensestg000000230601 flanking french genotyped intronic kif12 linkage lying orm1 portuguese positional refine replicate resequence resequenced rs3181357 spa spa2 spondylarthritis tnfsf15 tnfsf8 znf618	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?