ORM2 and CYP39A1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ORM2	CYP39A1
Gene Name		orosomucoid 2	cytochrome P450, family 39, subfamily A, polypeptide 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function		Iron Ion Binding Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity Heme Binding 24-hydroxycholesterol 7alpha-hydroxylase Activity
	Biological Process	Regulation Of Immune System Process Transport Acute-phase Response	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Xenobiotic Metabolic Process Digestion Bile Acid Metabolic Process Sterol Metabolic Process Bile Acid Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 24-hydroxycholesterol Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CYP39A1 PRDX6 STK3	4 interactors: GLUL ORM2 SERINC1 SMYD3
Entrez ID		5005	51302
HPRD ID		00725	07067
Ensembl ID		ENSG00000228278	ENSG00000146233
Uniprot IDs		P19652	B7Z786 Q9NYL5
PDB IDs		3APU 3APV 3APW 3APX
Enriched GO Terms of Interacting Partners?		Response To Reactive Oxygen Species Lipid Catabolic Process Bile Acid Catabolic Process Response To Oxidative Stress Primitive Hemopoiesis Cholesterol Catabolic Process Regulation Of Axon Regeneration Hydrogen Peroxide Catabolic Process Endocardium Development Hepatocyte Apoptotic Process Bile Acid Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Steroid Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Phospholipid Catabolic Process Hippo Signaling Embryonic Hemopoiesis Hydrogen Peroxide Metabolic Process Cell Differentiation Involved In Embryonic Placenta Development Bile Acid Metabolic Process Negative Regulation Of Organ Growth
Tagcloud ?		9q31 a1l4r1 af495724 ambp belgian boundaries c9orf91 ensestg000000230601 flanking french genotyped intronic kif12 linkage lying orm1 portuguese positional refine replicate resequence resequenced rs3181357 spa spa2 spondylarthritis tnfsf15 tnfsf8 znf618
Tagcloud (Difference) ?		9q31 a1l4r1 af495724 ambp belgian boundaries c9orf91 ensestg000000230601 flanking french genotyped intronic kif12 linkage lying orm1 portuguese positional refine replicate resequence resequenced rs3181357 spa spa2 spondylarthritis tnfsf15 tnfsf8 znf618
Tagcloud (Intersection) ?