ORM2 and PRDX6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ORM2	PRDX6
Description		orosomucoid 2	peroxiredoxin 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Catalytic Activity Peroxidase Activity Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity
	Biological Process	Regulation Of Immune System Process Acute-phase Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production	Lipid Metabolic Process Response To Oxidative Stress Lipid Catabolic Process Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification
Pathways		Platelet degranulation Neutrophil degranulation	Detoxification of Reactive Oxygen Species Neutrophil degranulation
Drugs		Disopyramide Lidocaine Imipramine Chlorpromazine Thalidomide Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	2-(N-morpholino)ethanesulfonic acid Copper
Diseases
GWAS			Adult body size ( 32376654) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)
Interacting Genes		3 interacting genes: CYP39A1 PRDX6 STK3	22 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SEPHS2 SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE
Entrez ID		5005	9588
HPRD ID		00725	03817
Ensembl ID		ENSG00000228278	ENSG00000117592
Uniprot IDs		P19652	P30041 V9HWC7
PDB IDs		3APU 3APV 3APW 3APX 7OUB	1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?		Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Primitive Hemopoiesis Neural Tube Formation Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Lipid Catabolic Process Cholesterol Catabolic Process BBSome	Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nuclear Receptor Activity Positive Regulation Of Telomere Maintenance Death Effector Domain Binding Response To Stress Intracellular Receptor Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Response To Estradiol Ripoptosome Positive Regulation Of Metabolic Process Response To External Biotic Stimulus CD95 Death-inducing Signaling Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Shelterin Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Telomere Cap Complex Nucleus G-rich Strand Telomeric DNA Binding Connective Tissue Development Telomere Capping Apoptotic Process Response To Vitamin Response To Vitamin A Programmed Cell Death Cell Death Protein Tag Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Interleukin-1 Beta Production Telomere Maintenance Positive Regulation Of Execution Phase Of Apoptosis Glutathione Peroxidase Activity Face Development Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Regulation Of Interleukin-1 Production Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Response To Ethanol Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding
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