ATP5F1A and SHBG

Number of citations of the paper that reports this interaction (PubMedID 15862967)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATP5F1A	SHBG
Description		ATP synthase F1 subunit alpha	sex hormone binding globulin
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Proton-transporting Two-sector ATPase Complex Membrane Raft Proton-transporting ATP Synthase Complex Extracellular Exosome Transmembrane Transporter Complex	Extracellular Region Extracellular Exosome
	Molecular Function	Nucleotide Binding Protease Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Adenyl Ribonucleotide Binding MHC Class I Protein Binding ADP Binding Angiostatin Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism	Steroid Binding Androgen Binding Protein Binding Lipid Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process ATP Biosynthetic Process Monoatomic Ion Transport Response To Muscle Activity Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Ethanol ATP Metabolic Process Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Proton Transmembrane Transport
Pathways		Mitochondrial protein import Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Artenimol	Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS			A body shape index ( 34021172) Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Estradiol levels ( 34255042) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		24 interacting genes: ABCC1 AIMP1 AIRE APP ATP5F1C ATPAF2 CSNK2A1 FNDC3B HSD17B10 HSPB2 LINC00941 LINC01554 NPSR1 OGT PTEN PTPRF SCGN SHBG SMARCB1 TNK2 YWHAB YWHAG YWHAQ YWHAZ	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SPMIP6 SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		498	6462
HPRD ID		01258	01646
Ensembl ID		ENSG00000152234	ENSG00000129214
Uniprot IDs		P25705 V9HW26	B0FWH2 B0FWH8 I3L145 P04278
PDB IDs		8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Protein Targeting Negative Regulation Of Translational Initiation Phosphoserine Residue Binding Protein Sequestering Activity Identical Protein Binding TORC1 Signaling Regulation Of Translation Protein Domain Specific Binding TOR Signaling Protein Localization To Vacuole Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Translational Initiation Sin3-type Complex Regulation Of TORC1 Signaling Post-transcriptional Regulation Of Gene Expression Central Tolerance Induction To Self Antigen Peripheral T Cell Tolerance Induction Positive Regulation Of Transcription By RNA Polymerase II Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction Reproductive Behavior Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Synaptic Vesicle Clustering Chondroitin Sulfate Proteoglycan Binding Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of TOR Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Glucagon Secretion Negative Regulation Of Defecation Synapse	Extracellular Exosome Protease Binding Cell-cell Junction Fructose Biosynthetic Process Detoxification Of Copper Ion Extracellular Space Glucose 6-phosphate:phosphate Antiporter Activity Cellular Response To Cadmium Ion Lamellipodium Cellular Response To Zinc Ion Cellular Response To Copper Ion Mesenchyme Migration Glucose-6-phosphate Transport Negative Regulation Of Cardiac Muscle Contraction Intracellular Zinc Ion Homeostasis Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Copper Ion Rough Endoplasmic Reticulum Hexose Metabolic Process Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Striated Muscle Contraction Response To Cadmium Ion Cell-cell Junction Organization Caveola Assembly Carbohydrate Metabolic Process Monosaccharide Metabolic Process Plasma Membrane Raft Assembly Response To Zinc Ion
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