ATP5F1A and AIRE

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ATP5F1A	AIRE
Description		ATP synthase F1 subunit alpha	autoimmune regulator
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Proton-transporting Two-sector ATPase Complex Membrane Raft Proton-transporting ATP Synthase Complex Extracellular Exosome Transmembrane Transporter Complex	Male Germ Cell Nucleus Female Germ Cell Nucleus Nucleus Cytoplasm Nuclear Body
	Molecular Function	Nucleotide Binding Protease Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Adenyl Ribonucleotide Binding MHC Class I Protein Binding ADP Binding Angiostatin Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Translation Regulator Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process ATP Biosynthetic Process Monoatomic Ion Transport Response To Muscle Activity Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Ethanol ATP Metabolic Process Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Proton Transmembrane Transport	Peripheral T Cell Tolerance Induction Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Translation Immune Response Humoral Immune Response Positive Regulation Of Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration
Pathways		Mitochondrial protein import Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Artenimol
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Addison's disease ( 33574239) Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114) Type 1 diabetes ( 34012112)
Interacting Genes		24 interacting genes: ABCC1 AIMP1 AIRE APP ATP5F1C ATPAF2 CSNK2A1 FNDC3B HSD17B10 HSPB2 LINC00941 LINC01554 NPSR1 OGT PTEN PTPRF SCGN SHBG SMARCB1 TNK2 YWHAB YWHAG YWHAQ YWHAZ	8 interacting genes: ATP5F1A CREBBP DAXX H2BC21 H3C1 HEXB PICK1 UBAC1
Entrez ID		498	326
HPRD ID		01258	06301
Ensembl ID		ENSG00000152234	ENSG00000160224
Uniprot IDs		P25705 V9HW26	O43918
PDB IDs		8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3	1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Protein Targeting Negative Regulation Of Translational Initiation Phosphoserine Residue Binding Protein Sequestering Activity Identical Protein Binding TORC1 Signaling Regulation Of Translation Protein Domain Specific Binding TOR Signaling Protein Localization To Vacuole Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Translational Initiation Sin3-type Complex Regulation Of TORC1 Signaling Post-transcriptional Regulation Of Gene Expression Central Tolerance Induction To Self Antigen Peripheral T Cell Tolerance Induction Positive Regulation Of Transcription By RNA Polymerase II Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction Reproductive Behavior Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Synaptic Vesicle Clustering Chondroitin Sulfate Proteoglycan Binding Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of TOR Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Glucagon Secretion Negative Regulation Of Defecation Synapse	P53 Binding Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Extracellular Exosome Chromatin Remodeling Adenyl Ribonucleotide Binding Beta-N-acetylglucosaminidase Activity Male Courtship Behavior Chromatin Organization Histone H3K27 Acetyltransferase Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Beta-N-acetylhexosaminidase Complex Structural Constituent Of Chromatin Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Chondroitin Sulfate Proteoglycan Catabolic Process Hexosaminidase Activity Nucleosome
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