SHC2 and NTRK1

Number of citations of the paper that reports this interaction (PMID 9507002)
13

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SHC2	NTRK1
Gene Name		SHC (Src homology 2 domain containing) transforming protein 2	neurotrophic tyrosine kinase, receptor, type 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding
	Biological Process	Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway Signal attenuation Signaling by VEGF Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Signalling to RAS SHC-mediated signalling Signaling by Insulin receptor	Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation
Drugs			Amitriptyline Imatinib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		8 interactors: EGFR ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3	36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		25759	4914
HPRD ID		19296	01869
Ensembl ID		ENSG00000129946	ENSG00000198400
Uniprot IDs		P98077	P04629
PDB IDs			1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Rhythmic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Phosphatidylinositol-mediated Signaling Cell Motility Regulation Of Signaling Cell Surface Receptor Signaling Pathway Phosphorylation Positive Regulation Of Protein Kinase Activity Circadian Rhythm Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Epithelium Development Regulation Of ERK1 And ERK2 Cascade Neuron Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity
Tagcloud ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Difference) ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Intersection) ?