SHC2 and KDR

Number of citations of the paper that reports this interaction (PMID 9790910)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		SHC2	KDR
Gene Name		SHC (Src homology 2 domain containing) transforming protein 2	kinase insert domain receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Extracellular Region Nucleus Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Membrane Raft Sorting Endosome
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Hsp90 Protein Binding
	Biological Process	Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway	Angiogenesis Ovarian Follicle Development Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mesenchymal Cell Proliferation Endothelium Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Extracellular Matrix Organization Positive Regulation Of Cell Migration Embryonic Hemopoiesis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of MAPK Cascade Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Cell Maturation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Focal Adhesion Assembly Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway Signal attenuation Signaling by VEGF Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Signalling to RAS SHC-mediated signalling Signaling by Insulin receptor	VEGF binds to VEGFR leading to receptor dimerization EPHA-mediated growth cone collapse VEGF ligand-receptor interactions Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF EPH-Ephrin signaling Neurophilin interactions with VEGF and VEGFR Integrin cell surface interactions VEGFA-VEGFR2 Pathway
Drugs			Sorafenib Sunitinib N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA Pazopanib Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		8 interactors: EGFR ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3	49 interactors: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 FBXO25 FBXW11 FIGF FLT1 FLT4 FRS2 FYN GNA11 GNAQ GRB10 GRB2 HSP90AA1 IQGAP1 ITGB3 NCK1 NRP1 P2RY2 PLCG1 PLCG2 PTPN11 PTPN6 RASA1 SH2D2A SHB SHC1 SHC2 SRC STAT1 SYNGAP1 TIMP3 UBC VEGFA VEGFC YES1
Entrez ID		25759	3791
HPRD ID		19296	01867
Ensembl ID		ENSG00000129946	ENSG00000128052
Uniprot IDs		P98077	P35968
PDB IDs			1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Rhythmic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Phosphatidylinositol-mediated Signaling Cell Motility Regulation Of Signaling Cell Surface Receptor Signaling Pathway Phosphorylation Positive Regulation Of Protein Kinase Activity Circadian Rhythm Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Epithelium Development Regulation Of ERK1 And ERK2 Cascade Neuron Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Body Fluid Levels Response To Growth Factor Anatomical Structure Morphogenesis Response To Wounding Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Platelet Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process System Development Response To Organic Substance Cardiovascular System Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Development Cell Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Leukocyte Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Blood Vessel Development Cellular Response To Peptide Positive Regulation Of Metabolic Process Angiogenesis
Tagcloud ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Difference) ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Intersection) ?