SHC2

Description		SHC adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane
	Molecular Function	Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction
Pathways		Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Novel Interacting Genes		1 novel interacting genes: RPL36
Interacting Genes		12 interacting genes: EGFR ERBB2 ERBB3 ERBB4 FLT1 GRB2 KDR KIT MET NTRK1 NTRK2 NTRK3
Entrez ID		25759
HPRD ID		19296
Ensembl ID		ENSG00000129946
Uniprot IDs		P98077
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Neuron Differentiation ATP Binding Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Growth Factor Binding Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Nucleotide Binding Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Protein Phosphorylation ERBB Signaling Pathway Phosphorylation Regulation Of Programmed Cell Death Cellular Developmental Process Myelination Axon Ensheathment Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cell Development Positive Regulation Of Phosphate Metabolic Process
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