SHC2

Gene Name		SHC (Src homology 2 domain containing) transforming protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway
Pathways		Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway Signal attenuation Signaling by VEGF Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Signalling to RAS SHC-mediated signalling Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: EGFR ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3
Entrez ID		25759
HPRD ID		19296
Ensembl ID		ENSG00000129946
Uniprot IDs		P98077
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Rhythmic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Phosphatidylinositol-mediated Signaling Cell Motility Regulation Of Signaling Cell Surface Receptor Signaling Pathway Phosphorylation Positive Regulation Of Protein Kinase Activity Circadian Rhythm Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Epithelium Development Regulation Of ERK1 And ERK2 Cascade Neuron Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity
Tagcloud ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308