SHC2 and NTRK2

Number of citations of the paper that reports this interaction (PMID 9507002)
13

Data Source:
HPRD (in vivo)

		SHC2	NTRK2
Gene Name		SHC (Src homology 2 domain containing) transforming protein 2	neurotrophic tyrosine kinase, receptor, type 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis
Pathways		Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway Signal attenuation Signaling by VEGF Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Signalling to RAS SHC-mediated signalling Signaling by Insulin receptor	Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS			Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		8 interactors: EGFR ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3	29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		25759	4915
HPRD ID		19296	02712
Ensembl ID		ENSG00000129946	ENSG00000148053
Uniprot IDs		P98077	Q16620 Q548C2 Q5VWE5
PDB IDs			1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Rhythmic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Phosphatidylinositol-mediated Signaling Cell Motility Regulation Of Signaling Cell Surface Receptor Signaling Pathway Phosphorylation Positive Regulation Of Protein Kinase Activity Circadian Rhythm Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Epithelium Development Regulation Of ERK1 And ERK2 Cascade Neuron Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?