ATP6AP1 and ABCD1

		ATP6AP1	ABCD1
Description		ATPase H+ transporting accessory protein 1	ATP binding cassette subfamily D member 1
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Endomembrane System Membrane Proton-transporting Two-sector ATPase Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase Complex Synapse Extracellular Exosome Bounding Membrane Of Organelle	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	ATPase Activator Activity Protein Binding Small GTPase Binding Transporter Activator Activity	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Organophosphate Ester Transmembrane Transporter Activity ABC-type Fatty-acyl-CoA Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Amide Transmembrane Transporter Activity ADP Binding Fatty Acyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity Sulfur Compound Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Cellular PH Osteoclast Development Cellular Response To Increased Oxygen Levels Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Endosome To Plasma Membrane Protein Transport Proton Transmembrane Transport	Very Long-chain Fatty Acid Metabolic Process Regulation Of Oxidative Phosphorylation Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Peroxisome Organization Organophosphate Ester Transport Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Nucleobase-containing Compound Transport Regulation Of Fatty Acid Metabolic Process Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Amide Transport Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Fatty Acid Derivative Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		Insulin receptor recycling RHOA GTPase cycle Transferrin endocytosis and recycling Ion channel transport	ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import
Drugs		Tiludronic acid
Diseases			Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS			Glycated hemoglobin levels ( 34059833)
Interacting Genes		6 interacting genes: ANG ERBB2 HBA1 NR1I2 OGT RHOU	5 interacting genes: ABCD2 ABCD3 PEX19 RPSA SLC27A2
Entrez ID		537	215
HPRD ID		02184	02300
Ensembl ID		ENSG00000071553	ENSG00000101986
Uniprot IDs		A0A384MQW4 Q15904	P33897
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	7RR9 7RRA 7SHM 7SHN 7VR1 7VWC 7VX8 7VZB 7X07 7X0T 7X0Z 7X1W 7XEC 7YRQ
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process Sulfur Compound Transmembrane Transporter Activity Positive Regulation Of Lipid Biosynthetic Process Fatty-acyl-CoA Transport Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty-acyl-CoA Catabolic Process Amide Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Homeostatic Process ABC-type Fatty-acyl-CoA Transporter Activity Catabolic Process Cytosol Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization TRNA-specific Ribonuclease Activity Regulation Of Translation Cytoplasmic Stress Granule Membraneless Organelle Assembly Angiogenin-PRI Complex Negative Regulation Of Catabolic Process Regulation Of Protein Localization Translation Positive Regulation Of Establishment Of Protein Localization XPC Complex RNA Polymerase I Core Binding ERBB3:ERBB2 Complex Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Translation Haptoglobin Binding 5'-deoxynucleotidase Activity Adenosine Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation TOR Signaling Positive Regulation Of Translational Initiation TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity Cellular Response To Rapamycin Regulation Of Translational Initiation Nucleoside Phosphate Catabolic Process Regulation Of Biological Quality Regulation Of Generation Of Precursor Metabolites And Energy Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Import Into Peroxisome Cytoplasmic Translation	Very Long-chain Fatty Acid Catabolic Process Peroxisomal Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Peroxisomal Membrane Transport Peroxisome Peroxisome Organization Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Long-chain Fatty Acid Import Into Peroxisome Methyl-branched Fatty Acid Metabolic Process Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Monocarboxylic Acid Transport Fatty Acyl-CoA Hydrolase Activity Lipid Modification Bile Acid Biosynthetic Process Carboxylic Acid Catabolic Process ATPase-coupled Transmembrane Transporter Activity Bile Acid Metabolic Process Intracellular Lipid Transport Carboxylic Acid Transport Organic Acid Transport Carboxylic Acid Biosynthetic Process Lipid Catabolic Process ABC-type Transporter Activity Fatty Acid Metabolic Process Lipid Transport Fatty Acid Derivative Biosynthetic Process Organic Anion Transport Intracellular Transport Fatty Acid Derivative Metabolic Process Small Molecule Biosynthetic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Monocarboxylic Acid Metabolic Process Lipid Biosynthetic Process Fatty Acid Biosynthetic Process Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Phytanic Acid Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Organic Acid Transmembrane Transport
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