GRIA2 and GRIP2

Number of citations of the paper that reports this interaction (PMID 9768844)
61

Data Source:
HPRD (in vivo, two hybrid)

		GRIA2	GRIP2
Gene Name		glutamate receptor, ionotropic, AMPA 2	glutamate receptor interacting protein 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane	Cytosol Plasma Membrane
	Molecular Function	Ionotropic Glutamate Receptor Activity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding	Receptor Signaling Complex Scaffold Activity
	Biological Process	Signal Transduction Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic	Synaptic Transmission
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative (S)-Des-Me-Ampa AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualate (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (S)-ATPA Dnqx Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA N,N\'-[biphenyl-4,4\'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		12 interactors: DRD2 GRIA3 GRIP1 GRIP2 GTF3C2 NSF PICK1 PRKCA SDCBP SPTAN1 SPTBN1 SQSTM1	4 interactors: CSPG4 GFI1B GRIA2 GRIA3
Entrez ID		2891	80852
HPRD ID		04726	18994
Ensembl ID		ENSG00000120251
Uniprot IDs		I6L997 P42262	Q9C0E4
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8	1V62 1X5R
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Neuron Development Neuron Differentiation Response To External Stimulus Cell Projection Organization Protein Localization Signaling Protein Localization To Membrane Regulation Of Vesicle-mediated Transport Cell Communication Neuron Projection Development Positive Regulation Of Receptor Internalization Membrane Organization Intracellular Transport Negative Regulation Of Adenylate Cyclase Activity Cell Differentiation Generation Of Neurons Negative Regulation Of Lyase Activity Golgi To Plasma Membrane Protein Transport Negative Regulation Of Cytoskeleton Organization Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Axonogenesis Regulation Of Receptor Internalization Negative Regulation Of CAMP Metabolic Process Cell Development Golgi To Plasma Membrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Receptor-mediated Endocytosis Chemotaxis Negative Regulation Of Nucleotide Metabolic Process Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell Regulation Of Secretion Neuron Projection Morphogenesis Locomotion Golgi Vesicle Transport Cell Surface Receptor Signaling Pathway Actin Filament Capping Cell Morphogenesis Involved In Differentiation Regulation Of Adenylate Cyclase Activity Nervous System Development Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Positive Regulation Of Metabolic Process Neuron-neuron Synaptic Transmission	Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process
Tagcloud ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria1 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria1 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?