GRIA2 and GRIP2

Number of citations of the paper that reports this interaction (PubMedID 9768844)
0

Data Source:
HPRD (in vivo, two hybrid)

		GRIA2	GRIP2
Description		glutamate ionotropic receptor AMPA type subunit 2	glutamate receptor interacting protein 2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Postsynapse Postsynaptic Density Membrane Postsynaptic Endocytic Zone	Cytoplasm Cytosol Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Monoatomic Cation Transmembrane Transport	Notch Signaling Pathway Artery Smooth Muscle Contraction Positive Regulation Of Blood Pressure Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Activation of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation MECP2 regulates neuronal receptors and channels Long-term potentiation	Trafficking of GluR2-containing AMPA receptors
Drugs		Glutamic acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Ethanol Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione (S)-DES-ME-AMPA (S)-AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualic acid (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoate FG-9041 Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA Talampanel CX-717 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Fluciclovine (18F)
Diseases
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)	Cognitive performance ( 19734545) Sjögren's syndrome ( 28076899)
Interacting Genes		21 interacting genes: CTTN CYLD DRD2 FXR1 GAPDH GRIA3 GRIP2 GSK3B GTF3C2 ITGB3 NSF PICK1 PRKCA RAC1 RNF167 SDCBP SPTAN1 SPTBN1 SQSTM1 SYT3 TSPAN7	6 interacting genes: CSPG4 FMR1 FXR1 GFI1B GRIA2 GRIA3
Entrez ID		2891	80852
HPRD ID		04726	18994
Ensembl ID		ENSG00000120251	ENSG00000144596
Uniprot IDs		A0A994J4F1 P42262	Q9C0E4
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG 5ZG0 5ZG1 5ZG2 5ZG3 7F3O 8I0B	1V62 1X5R
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Plasma Membrane Regulation Of Synaptic Plasticity Regulation Of Biological Quality Positive Regulation Of Signaling Regulation Of Organelle Organization Synapse Modulation Of Chemical Synaptic Transmission Regulation Of Signaling Regulation Of Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Cellular Component Organization Chemical Synaptic Transmission Regulation Of Receptor Internalization Localization Within Membrane Trans-synaptic Signaling Regulation Of Actin Cytoskeleton Organization Synaptic Signaling Regulation Of Secretion By Cell Alphav-beta3 Integrin-PKCalpha Complex Vesicle-mediated Transport Regulation Of Actin Filament-based Process Ionotropic Glutamate Receptor Binding Regulation Of Secretion Cellular Component Assembly Postsynapse Membrane Membrane Organization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Size Positive Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Actin Filament Polymerization Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Organization Positive Regulation Of Developmental Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Neuron Projection Organization Regulation Of Actin Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Actin Filament Length Intracellular Membraneless Organelle	Dendritic Spine Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Glutamate Receptor Signaling Pathway RNA Strand Annealing Activity AMPA Glutamate Receptor Activity Intracellular Membraneless Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Glutamate-gated Receptor Activity Positive Regulation Of MiRNA-mediated Gene Silencing Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing AMPA Glutamate Receptor Complex Regulation Of Post-transcriptional Gene Silencing Postsynapse Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Synapse Molecular Condensate Scaffold Activity Regulation Of Neuronal Synaptic Plasticity Endocytic Vesicle Membrane Regulation Of Membrane Potential Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Intracellular Transport Of Viral Material Dendrite Amyloid-beta Binding Cytoplasmic Stress Granule Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Dendritic Filopodium Histone H3 Reader Activity MRNA Transport MRNA 3'-UTR Binding Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Ligand-gated Monoatomic Cation Channel Activity RNA Transport Positive Regulation Of Translation Monoatomic Ion Channel Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication
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