GRIA2 and GTF3C2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GRIA2	GTF3C2
Gene Name		glutamate receptor, ionotropic, AMPA 2	general transcription factor IIIC, polypeptide 2, beta 110kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane	Transcription Factor TFIIIC Complex Nucleoplasm
	Molecular Function	Ionotropic Glutamate Receptor Activity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding	DNA Binding
	Biological Process	Signal Transduction Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Gene Expression 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs		L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative (S)-Des-Me-Ampa AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualate (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (S)-ATPA Dnqx Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA N,N\'-[biphenyl-4,4\'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
Diseases
GWAS
Protein-Protein Interactions		12 interactors: DRD2 GRIA3 GRIP1 GRIP2 GTF3C2 NSF PICK1 PRKCA SDCBP SPTAN1 SPTBN1 SQSTM1	5 interactors: GRIA2 GTF3A GTF3C4 RB1 TBP
Entrez ID		2891	2976
HPRD ID		04726	05347
Ensembl ID		ENSG00000120251	ENSG00000115207
Uniprot IDs		I6L997 P42262	Q8WUA4
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Neuron Development Neuron Differentiation Response To External Stimulus Cell Projection Organization Protein Localization Signaling Protein Localization To Membrane Regulation Of Vesicle-mediated Transport Cell Communication Neuron Projection Development Positive Regulation Of Receptor Internalization Membrane Organization Intracellular Transport Negative Regulation Of Adenylate Cyclase Activity Cell Differentiation Generation Of Neurons Negative Regulation Of Lyase Activity Golgi To Plasma Membrane Protein Transport Negative Regulation Of Cytoskeleton Organization Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Axonogenesis Regulation Of Receptor Internalization Negative Regulation Of CAMP Metabolic Process Cell Development Golgi To Plasma Membrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Receptor-mediated Endocytosis Chemotaxis Negative Regulation Of Nucleotide Metabolic Process Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell Regulation Of Secretion Neuron Projection Morphogenesis Locomotion Golgi Vesicle Transport Cell Surface Receptor Signaling Pathway Actin Filament Capping Cell Morphogenesis Involved In Differentiation Regulation Of Adenylate Cyclase Activity Nervous System Development Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Positive Regulation Of Metabolic Process Neuron-neuron Synaptic Transmission	Transcription From RNA Polymerase III Promoter RRNA Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin DNA-templated Transcription, Initiation Attachment Of Mitotic Spindle Microtubules To Kinetochore 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter TRNA Transcription RNA Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Gene Expression Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macrophage Differentiation Macromolecule Biosynthetic Process Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation Chromatin Silencing At RDNA Transcription Initiation From RNA Polymerase III Promoter Positive Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Cohesion Hepatocyte Apoptotic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Viral Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Mitotic Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Protein Localization To Chromosome Chromatin Modification Neuron Maturation Sister Chromatid Cohesion Transcription From RNA Polymerase I Promoter Metaphase Plate Congression Negative Regulation Of Smoothened Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Chromatin Silencing Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria1 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Difference) ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria1 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Intersection) ?