GRIA2 and GTF3C2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GRIA2	GTF3C2
Name		glutamate ionotropic receptor AMPA type subunit 2	general transcription factor IIIC subunit 2
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Postsynapse Postsynaptic Density Membrane Postsynaptic Endocytic Zone	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Monoatomic Cation Transmembrane Transport	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		Activation of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation MECP2 regulates neuronal receptors and channels Long-term potentiation	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs		Glutamic acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Ethanol Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione (S)-DES-ME-AMPA (S)-AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualic acid (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoate FG-9041 Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA Talampanel CX-717 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Fluciclovine (18F)	None
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883 )	Menopause (age at onset) ( 26414677 ) Metabolite levels ( 23823483 ) Urinary albumin-to-creatinine ratio ( 32600054 )
Interacting Genes		21 interacting genes: CTTN CYLD DRD2 FXR1 GAPDH GRIA3 GRIP2 GSK3B GTF3C2 ITGB3 NSF PICK1 PRKCA RAC1 RNF167 SDCBP SPTAN1 SPTBN1 SQSTM1 SYT3 TSPAN7	10 interacting genes: GRIA2 GTF3A GTF3C4 MECOM PTEN RB1 SUMO2 TBP VAC14 VHL
Entrez ID		2891	2976
HPRD ID		04726	05347
Ensembl ID		ENSG00000120251	ENSG00000115207
Uniprot IDs		A0A994J4F1 P42262	Q8WUA4
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG 5ZG0 5ZG1 5ZG2 5ZG3 7F3O 8I0B	8CLI 8CLJ 8CLL
GO Terms Enriched among Interactors		Glutamatergic Synapse Plasma Membrane Regulation Of Synaptic Plasticity Regulation Of Biological Quality Positive Regulation Of Signaling Regulation Of Organelle Organization Synapse Modulation Of Chemical Synaptic Transmission Regulation Of Signaling Regulation Of Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Cellular Component Organization Chemical Synaptic Transmission Regulation Of Receptor Internalization Localization Within Membrane Trans-synaptic Signaling Regulation Of Actin Cytoskeleton Organization Synaptic Signaling Regulation Of Secretion By Cell Alphav-beta3 Integrin-PKCalpha Complex Vesicle-mediated Transport Regulation Of Actin Filament-based Process Ionotropic Glutamate Receptor Binding Regulation Of Secretion Cellular Component Assembly Postsynapse Membrane Membrane Organization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Size Positive Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Actin Filament Polymerization Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Organization Positive Regulation Of Developmental Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Neuron Projection Organization Regulation Of Actin Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Actin Filament Length Intracellular Membraneless Organelle	Transcription By RNA Polymerase III PML Body RNA Polymerase III General Transcription Initiation Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription RRNA Transcription Enzyme Binding DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering PAS Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Chromatin Lock Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Histone H3K9 Monomethyltransferase Activity Dendritic Spine AMPA Glutamate Receptor Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Negative Regulation Of Nervous System Development Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity